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Literature summary extracted from

  • Heidrich, J.E.; Contos, L.M.; Hunsaker, L.A.; Deck, L.M.; Vander Jagt, D.L.
    Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster (2004), BMC Pharmacol., 4, 5.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.1.13 medicine selective inhibitors may be useful therapeutics for limiting cholesterol absorption Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 3-benzyl-6-chloro-2-pyrone less selective, potent inhibitor Mesocricetus auratus
3.1.1.13 6-chloro-3-(1-ethyl-2-cyclohexyl)-2-pyrone selective, potent, and reversible inhibitor, not toxic in vivo, enzyme inhibition effectively reduces cholesterol uptake in vivo Mesocricetus auratus
3.1.1.13 additional information substituted 6-chloro-2-pyrones can be simple reversible inhibitors or irreversible active site inhibitors where an active site nucleophile attacks the 6-postion of the pyrone with release of chloride Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.13 cholesteryl oleate + H2O Mesocricetus auratus
-
 cholesterol + oleate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Mesocricetus auratus
-
 male
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.13 steryl ester + H2O = sterol + fatty acid a group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts Mesocricetus auratus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 intestine
-
 Mesocricetus auratus
-
3.1.1.13 pancreas
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl oleate + H2O
-
 Mesocricetus auratus cholesterol + oleate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 CEase
-
 Mesocricetus auratus
3.1.1.13 cholesterol esterase
-
 Mesocricetus auratus