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Literature summary extracted from

  • Kokame, K.; Matsumoto, M.; Fujimura, Y.; Miyata, T.
    VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13 (2003), Blood, 103, 607-612.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.87 Urea required Homo sapiens

Application

EC Number Application Comment Organism
3.4.24.87 medicine VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13. VWF73 could be a powerful tool to establish clinical enzymatic assays. It may contribute to improve the prognosis and prevention of thrombotic thrombocytopenic purpurea Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.87 expression of a series of partial deletions in the A2 domain flanked with N- and C-terminal tags in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.87 additional information inhibition by autoantibodies from patients with acquired thrombotic thrombocytopenic purpura Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.87 extracellular plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.87 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.87 von Willebrand factor + H2O Homo sapiens either congenital or acquired defects of the enzyme lead to thrombotic thromcytopenic purpura, cleavage of the peptide bond bond Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 2 peptides of 140 kDa and 176 kDa
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.87 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.87 recombinant tagged deletion mutants Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.87 The enzyme cleaves the von Willebrand factor at bond Tyr842-/-Met843 within the A2 domain enzyme is a hemostatic factor Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.87 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.87 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.87 von Willebrand factor + H2O specific cleavage of the peptide bond Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 Homo sapiens 2 peptides of 140 kDa and 176 kDa
-
 ?
3.4.24.87 von Willebrand factor + H2O either congenital or acquired defects of the enzyme lead to thrombotic thromcytopenic purpura, cleavage of the peptide bond bond Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 Homo sapiens 2 peptides of 140 kDa and 176 kDa
-
 ?
3.4.24.87 von Willebrand factor + H2O VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13 Homo sapiens ?
-
 ?
3.4.24.87 VWF73 region of von Willebrand factor + H2O with this minimal substrate urea is not required for cleavage, minimal substrate for ADAMTS-13 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.87 ADAMTS-13
-
 Homo sapiens
3.4.24.87 M12.241 Merops-ID Homo sapiens
3.4.24.87 von Willebrand factor-cleaving protease
-
 Homo sapiens