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Literature summary extracted from

  • Lee, J.; Kang, S.U.; Kim, S.Y.; Kim, S.E.; Kang, M.K.; Jo, Y.J.; Kim, S.
    Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases (2001), Bioorg. Med. Chem. Lett., 11, 961-964.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.1.1.5 molecular biology enzyme is a target for receptor-guided inhibitor design Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.5 ester analogues of isoleucyl adenylate with or without cyclic substitutents at the adenine moiety Escherichia coli
6.1.1.5 hydroxamate analogues of isoleucyl adenylate with or without cyclic substitutents at the adenine moiety Escherichia coli
6.1.1.5 additional information inhibition mechanism and structural determinants Escherichia coli
6.1.1.10 ester analogues of L-methionyl adenylate overview, modeling of interaction with the active site Escherichia coli
6.1.1.10 hydroxamate analogues of L-methionyl adenylate overview, modeling of the interaction with the active site Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle Escherichia coli
-
 AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.10 ATP + L-methionine + tRNAMet Escherichia coli
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.5 Escherichia coli
-
-
-
6.1.1.10 Escherichia coli
-
 class I enzyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle
-
 Escherichia coli AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.5 ATP + L-isoleucine + tRNAIle the binding region of the adenine moiety contains a wide hydrophobic pocket large enough to afford three linear aromatic rings Escherichia coli AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.10 ATP + L-methionine + tRNAMet
-
 Escherichia coli AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.5 IleRS
-
 Escherichia coli
6.1.1.5 IRS
-
 Escherichia coli
6.1.1.5 Isoleucine translase
-
 Escherichia coli
6.1.1.5 Isoleucine--tRNA ligase
-
 Escherichia coli
6.1.1.5 Isoleucine-transfer RNA ligase
-
 Escherichia coli
6.1.1.5 Isoleucine-tRNA synthetase
-
 Escherichia coli
6.1.1.5 Isoleucyl-transfer ribonucleate synthetase
-
 Escherichia coli
6.1.1.5 Isoleucyl-transfer RNA synthetase
-
 Escherichia coli
6.1.1.5 Isoleucyl-tRNA synthetase
-
 Escherichia coli
6.1.1.5 Mupirocin resistance protein
-
 Escherichia coli
6.1.1.5 Synthetase, isoleucyl-transfer ribonucleate
-
 Escherichia coli
6.1.1.10 Methionine translase
-
 Escherichia coli
6.1.1.10 Methionine--tRNA ligase
-
 Escherichia coli
6.1.1.10 Methionyl tRNA synthetase
-
 Escherichia coli
6.1.1.10 Methionyl-transfer ribonucleate synthetase
-
 Escherichia coli
6.1.1.10 Methionyl-transfer ribonucleic acid synthetase
-
 Escherichia coli
6.1.1.10 Methionyl-transfer RNA synthetase
-
 Escherichia coli
6.1.1.10 MetRS
-
 Escherichia coli
6.1.1.10 Synthetase, methionyl-transfer ribonucleate
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.5 ATP
-
 Escherichia coli
6.1.1.10 ATP
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1.1.5 additional information
-
 additional information
-
 Escherichia coli
6.1.1.10 additional information
-
 additional information
-
 Escherichia coli