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Literature summary extracted from

  • Yu, X.Y.; Hill, J.M.; Yu, G.; Yang, Y.; Kluge, A.F.; Keith, D.; Finn, J.; Gallant, P.; Silverman, J.; Lim, A.
    A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase (2001), Bioorg. Med. Chem. Lett., 11, 541-544.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.15 2-(2-chloro-thiophene)-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(2-chloro-thiophene)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(3,4-dichloro-phenyl)-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(3,4-dichloro-phenyl)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-5,7-dichloro-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-5,7-dichloro-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-5-methyl-7-chloro-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-5-methyl-7-chloro-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6,8-dimethyl-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6,8-dimethyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-(4-hydroxyphenyl)-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-(4-hydroxyphenyl)-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-(trifluoromethoxy)-4-quinolinecarboxylic acid strong inhibition Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-(trifluoromethoxy)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-alkenyl-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-alkenyl-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-amino-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-amino-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-bromo-4-quinolinecarboxylic acid strong inhibition Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-bromo-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-bromo-8-(trifluoromethyl)-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-bromo-8-(trifluoromethyl)-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-chloro-4-quinolinecarboxylic acid strong inhibition Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-chloro-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-chloro-8-hydroxymethyl-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-chloro-8-hydroxymethyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid best inhibitor, species-selective Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-iodo-4-quinolinecarboxylic acid strong inhibition Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-iodo-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-6-methyl-8-chloro-4-quinolinecarboxylic acid strong inhibition Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-6-methyl-8-chloro-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-7-bromo-8-methyl-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-7-bromo-8-methyl-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-bromo-phenyl)-7-fluoro-8-methyl-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-(4-bromo-phenyl)-7-fluoro-8-methyl-4-quinolinecarboxylic acid
-
 Homo sapiens
6.1.1.15 2-(4-methoxy-phenyl)-4-quinolinecarboxylic acid weak inhibition Candida albicans
6.1.1.15 2-(4-methoxy-phenyl)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-(4-[trifluoromethyl]-phenyl)-4-quinolinecarboxylic acid weak inhibition Candida albicans
6.1.1.15 2-(4-[trifluoromethyl]-phenyl)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-furyl-4-quinolinecarboxylic acid weak inhibition Candida albicans
6.1.1.15 2-furyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-naphthyl-4-quinolinecarboxylic acid
-
 Candida albicans
6.1.1.15 2-naphthyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-phenyl-4-quinolinecarboxylic acid weak inhibition Candida albicans
6.1.1.15 2-phenyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
6.1.1.15 2-pyridyl-4-quinolinecarboxylic acid weak inhibition Candida albicans
6.1.1.15 2-pyridyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro Homo sapiens
-
 AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
6.1.1.15 ATP + L-proline + tRNAPro Candida albicans
-
 AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.15 Candida albicans
-
-
-
6.1.1.15 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.15 ATP + L-proline + tRNAPro
-
 Homo sapiens AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
6.1.1.15 ATP + L-proline + tRNAPro
-
 Candida albicans AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.15 Global RNA synthesis factor
-
 Homo sapiens
6.1.1.15 Global RNA synthesis factor
-
 Candida albicans
6.1.1.15 Pro-tRNA synthetase
-
 Homo sapiens
6.1.1.15 Pro-tRNA synthetase
-
 Candida albicans
6.1.1.15 Proline translase
-
 Homo sapiens
6.1.1.15 Proline translase
-
 Candida albicans
6.1.1.15 Proline--tRNA ligase
-
 Homo sapiens
6.1.1.15 Proline--tRNA ligase
-
 Candida albicans
6.1.1.15 Prolyl RNA synthetase
-
 Homo sapiens
6.1.1.15 Prolyl RNA synthetase
-
 Candida albicans
6.1.1.15 Prolyl-transfer ribonucleate synthetase
-
 Homo sapiens
6.1.1.15 Prolyl-transfer ribonucleate synthetase
-
 Candida albicans
6.1.1.15 Prolyl-transfer ribonucleic acid synthetase
-
 Homo sapiens
6.1.1.15 Prolyl-transfer ribonucleic acid synthetase
-
 Candida albicans
6.1.1.15 Prolyl-transfer RNA synthetase
-
 Homo sapiens
6.1.1.15 Prolyl-transfer RNA synthetase
-
 Candida albicans
6.1.1.15 Prolyl-tRNA synthetase
-
 Homo sapiens
6.1.1.15 Prolyl-tRNA synthetase
-
 Candida albicans
6.1.1.15 ProRS
-
 Homo sapiens
6.1.1.15 ProRS
-
 Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.15 ATP
-
 Homo sapiens
6.1.1.15 ATP
-
 Candida albicans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1.1.15 additional information
-
 additional information
-
 Candida albicans