Literature summary extracted from

Madsen, P.; Jakobsen, P.; Westergaard, N.
N,N-dibenzyl-N'-benzylidenehydrazines: potent competitive glucose-6-phosphatase catalytic enzyme inhibitors (2001), Bioorg. Med. Chem. Lett., 11, 2165-2167.

Application

EC Number	Application	Comment	Organism
3.1.3.9	medicine	inhibitors of liver enzyme involved in either glycogenolysis or glyconeogenesis ara potential targets for development of new drugs as alternatives to the existing treatments of type 2 diabetes	Sus scrofa

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.3.9	3,4-dichlorobenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	3-methoxybenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	4-chlorobenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	4-hydroxybenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	4-methoxybenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	5-chlorotetrahydrothiophene-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	5-ethyltetrahydrofuran-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	benzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	isonicotinaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	additional information	a series of N,N-dibenzyl-N-benzylidnenhydrazine represent a novel class of potent competivitve D-glucose-6-phosphatase catalytic inhibitors using disrupted microsomes	Sus scrofa
3.1.3.9	nicotinaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	pyridine-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	tetrahydrofuran-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	tetrahydrothiophene-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.3.9	microsome	-	Sus scrofa	-	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.3.9	D-glucose 6-phosphate + H2O	Sus scrofa	enzyme catalyses the final step in both glycogenolysis and glyconeogenesis	D-glucose + phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.9	Sus scrofa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.9	liver	-	Sus scrofa	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.3.9	D-glucose 6-phosphate + H2O	-	Sus scrofa	D-glucose + phosphate	-	?
3.1.3.9	D-glucose 6-phosphate + H2O	enzyme catalyses the final step in both glycogenolysis and glyconeogenesis	Sus scrofa	D-glucose + phosphate	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3.1.3.9	additional information	-	additional information	-	Sus scrofa
3.1.3.9	0.00011	-	5-chlorotetrahydrothiophene-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.00014	-	4-methoxybenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.00015	-	4-chlorobenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.00045	-	3-methoxybenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.000704	-	tetrahydrofuran-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.00096	-	benzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.00096	-	tetrahydrothiophene-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.00128	-	3,4-dichlorobenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.00154	-	4-hydroxybenzaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.0064	-	pyridine-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.011	-	isonicotinaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.021	-	5-ethyltetrahydrofuran-2-carbaldehyde dibenzylhydrazone	-	Sus scrofa
3.1.3.9	0.237	-	nicotinaldehyde dibenzylhydrazone	-	Sus scrofa

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Release 2023.1 (January 2023)