Literature summary extracted from

Choi-Miura, N.H.; Saito, K.; Takahashi, K.; Yoda, M.; Tomita, M.
Regulation mechanism of the serine protease activity of plasma hyaluronan binding protein (2001), Biol. Pharm. Bull., 24, 221-225.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.B1	Dextran sulfate	enhances autofragmentation and serine protease activity	Homo sapiens
3.4.21.B1	phosphatidylethanolamine	enhances autofragmentation and serine protease activity at 0.001 mg/ml and 0.00001 mg/ml	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.B1	inhibitor C1	C1 inhibitor of the serpin family, forms a complex with the enzyme, 50% inhibition at 0.001 mg/ml	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.B1	Protein + H2O	Homo sapiens	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.B1	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.21.B1	-	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.B1	plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.B1	N-tert-butoxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O	synthetic substrate	Homo sapiens	N-tert-butoxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin	-	?
3.4.21.B1	Protein + H2O	-	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.B1	PHBP	-	Homo sapiens

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Release 2023.1 (January 2023)