BRENDA - Enzyme Database

Regulation mechanism of the serine protease activity of plasma hyaluronan binding protein

Choi-Miura, N.H.; Saito, K.; Takahashi, K.; Yoda, M.; Tomita, M.; Biol. Pharm. Bull. 24, 221-225 (2001)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.4.21.B1
Dextran sulfate
enhances autofragmentation and serine protease activity
Homo sapiens
3.4.21.B1
phosphatidylethanolamine
enhances autofragmentation and serine protease activity at 0.001 mg/ml and 0.00001 mg/ml
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.21.B1
inhibitor C1
C1 inhibitor of the serpin family, forms a complex with the enzyme, 50% inhibition at 0.001 mg/ml
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.4.21.B1
Protein + H2O
Homo sapiens
-
?
-
Homo sapiens
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.4.21.B1
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.4.21.B1
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.21.B1
plasma
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.4.21.B1
N-tert-butoxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
synthetic substrate
650490
Homo sapiens
N-tert-butoxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
650490
Homo sapiens
?
3.4.21.B1
Protein + H2O
-
650490
Homo sapiens
?
-
650490
Homo sapiens
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.4.21.B1
Dextran sulfate
enhances autofragmentation and serine protease activity
Homo sapiens
3.4.21.B1
phosphatidylethanolamine
enhances autofragmentation and serine protease activity at 0.001 mg/ml and 0.00001 mg/ml
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.21.B1
inhibitor C1
C1 inhibitor of the serpin family, forms a complex with the enzyme, 50% inhibition at 0.001 mg/ml
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.4.21.B1
Protein + H2O
Homo sapiens
-
?
-
Homo sapiens
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.4.21.B1
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.21.B1
plasma
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.4.21.B1
N-tert-butoxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
synthetic substrate
650490
Homo sapiens
N-tert-butoxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
650490
Homo sapiens
?
3.4.21.B1
Protein + H2O
-
650490
Homo sapiens
?
-
650490
Homo sapiens
?