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Literature summary extracted from

  • Etscheid, M.; Beer, N.; Fink, E.; Seitz, R.; Johannes, D.
    The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin (2002), Biol. Chem., 383, 1633-1643.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.B1 chondroitin sulfate increases kininogen cleavage at above 1 mg/ml Homo sapiens
3.4.21.B1 heparan sulfate increases kininogen cleavage at at 0.5-2 mg/ml Homo sapiens
3.4.21.B1 heparin increases kininogen cleavage at at 5-47 U/ml Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B1 high molecular weight kininogen profactor + H2O Homo sapiens activates kininogen, cleaves between Arg419 and Lys 420 activated kininogen + bradykinin
-
 ?
3.4.21.B1 Protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B1 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B1 high molecular weight kininogen + H2O activates kininogen Homo sapiens activated cofactor kininogen + bradykinin
-
 ?
3.4.21.B1 high molecular weight kininogen profactor + H2O activates kininogen, cleaves between Arg419 and Lys 420 Homo sapiens activated kininogen + bradykinin
-
 ?
3.4.21.B1 low molecular weight kininogen + H2O
-
 Homo sapiens bradykinin + ?
-
 ?
3.4.21.B1 Protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B1 PHBSP
-
 Homo sapiens