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Literature summary extracted from
- Factor VII activating protease (FSAP): a novel protease in hemostasis (2002), Biol. Chem., 383, 1119-1124.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.B1 | heparin | supports autoactivation | Homo sapiens |  |
| 3.4.21.B1 | poly-L-lysine | - |
Homo sapiens | |
| 3.4.21.B1 | urokinase | potential physiological activator | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.B1 | alpha2-antiplasmin | potent inhibitor | Homo sapiens | |
| 3.4.21.B1 | antithrombin | potent inhibitor only in presence of heparin | Homo sapiens | |
| 3.4.21.B1 | Aprotinin | - |
Homo sapiens | |
| 3.4.21.B1 | C1-inhibitor | potent inhibitor | Homo sapiens | |
| 3.4.21.B1 | Ca2+ | stabilizes proenzyme | Homo sapiens | |
| 3.4.21.B1 | inter-alpha-trypsin inhibitor | potent inhibitor | Homo sapiens |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.B1 | 64000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B1 | additional information | Homo sapiens | role in hemostasis is likely | ? | - |
? | |
| 3.4.21.B1 | Protein + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.B1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.B1 | kidney | - |
Homo sapiens | - |
| 3.4.21.B1 | liver | - |
Homo sapiens | - |
| 3.4.21.B1 | pancreas | - |
Homo sapiens | - |
| 3.4.21.B1 | plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.B1 | factor V + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | factor VII + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | factor VIII + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | kininogen + H2O | - |
Homo sapiens | bradykinin + ? | - |
? | |
| 3.4.21.B1 | additional information | role in hemostasis is likely | Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | Protein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | prourokinase + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | transcription factor of amyloid beta protein precursor + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.B1 | Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.B1 | factor seven activating protease | - |
Homo sapiens |
| 3.4.21.B1 | FSAP | - |
Homo sapiens |
| 3.4.21.B1 | PHBP | - |
Homo sapiens |
| 3.4.21.B1 | PHBSP | - |
Homo sapiens |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.21.B1 | Homo sapiens | - |
- |
4.9 |
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