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Literature summary extracted from

  • Lu, J.Y.; Verkruyse, L.A.; Hofmann, S.L.
    The effects of lysosomotropic agents on normal and INCL cells provide further evidence for the lysosomal nature of palmitoyl-protein thioesterase function (2002), Biochim. Biophys. Acta, 1583, 35-44.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.22 Chloroquine inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells Homo sapiens
3.1.2.22 leupeptin inhibits the hydrolysis and leads to accumulation of lipid cysteine thioesters in the lysosomes of treated cells but has no direct inhibitory effect on the enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.22 lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.22 additional information Homo sapiens enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.22 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.2.22 palmitoyl[protein] + H2O = palmitate + protein specific for long-chain thioesters of fatty acids from S-acylated residues in proteins, palmitoyl cysteine and palmitoyl-CoA Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.22 B-lymphoblastoid cell line transformed by Epstein-Barr virus Homo sapiens
-
3.1.2.22 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.22 additional information enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL, a lysosomal storage disorder Homo sapiens ?
-
 ?
3.1.2.22 palmitoyl-[protein] + H2O
-
 Homo sapiens palmitate + protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.22 palmitoyl-protein hydrolase
-
 Homo sapiens
3.1.2.22 Palmitoyl-protein thioesterase
-
 Homo sapiens
3.1.2.22 PPT
-
 Homo sapiens
3.1.2.22 PPT1
-
 Homo sapiens