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Literature summary extracted from

  • Tjoelker, L.W.; Stafforini, D.M.
    Platelet-activating factor acetylhydrolases in health and disease (2000), Biochim. Biophys. Acta, 1488, 102-123.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.47 corticoids regulatory function on the enzyme form from HL-60 cells Homo sapiens
3.1.1.47 corticoids regulatory function on the enzyme form from plasma Rattus norvegicus
3.1.1.47 GM-CSF regulatory function on the enzyme form from monocyte-derived macrophages Homo sapiens
3.1.1.47 interleukin-beta regulatory function on the enzyme form from plasma, liver and spleen Cricetinae
3.1.1.47 lipopolysaccharides regulatory function on the enzyme form from plasma Mus musculus
3.1.1.47 lipopolysaccharides regulatory function on the enzyme form from plasma, liver, spleen, lung, and small intestine Cricetinae
3.1.1.47 M-CSF regulatory function on the enzyme form from monocyte-derived macrophages Homo sapiens
3.1.1.47 platelet-activating factor regulatory function on the enzyme form from hepatocytes Rattus norvegicus
3.1.1.47 platelet-activating factor regulatory function on the enzyme form from HepG2 cells and monocyte-derived macrophages, no effect on erythrocytes and erythrocyte isozyme Homo sapiens
3.1.1.47 progestin regulatory function on the enzyme form from HL-60 cells Homo sapiens
3.1.1.47 progestin regulatory function on the enzyme form from plasma Rattus norvegicus
3.1.1.47 tumor necrosis factor-alpha regulatory function on the enzyme form from plasma, liver and spleen Cricetinae
3.1.1.47 turpentine regulatory function on the enzyme form from plasma Rattus norvegicus
3.1.1.47 zymosan regulatory function on the enzyme form from plasma Rattus norvegicus

Application

EC Number Application Comment Organism
3.1.1.47 medicine recombinant plasma enzyme form can prevent or attenuate pathological inflammation in a number of animal models, it may have pharmacological potential in human inflammatory disease as well, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.47
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.47 additional information several naturally occurring mutations of different populations are connected with diseases in humans, overview Homo sapiens
3.1.1.47 Q281R naturally occurring mutation in japanes population, inactive mutant enzyme, associated with asthma Homo sapiens
3.1.1.47 V297F common naturally occurring mutation in japanese population, inactive mutant enzyme, prevalence of the mutant allele is significantly higher in patients with asthma, stroke, myocardial infraction, brain hemorrhage, and nonfamilial cardiomyopathy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 corticoids regulatory function on the enzyme form from HL-60 cells Homo sapiens
3.1.1.47 croton oil regulatory function on the enzyme form from plasma Oryctolagus cuniculus
3.1.1.47 Estrogens regulatory function on the enzyme form from plasma Rattus norvegicus
3.1.1.47 IFN-gamma regulatory function on the enzyme form from monocyte-derived macrophages Homo sapiens
3.1.1.47 interleukin-1alpha regulatory function on the enzyme form from decidual macrophages Homo sapiens
3.1.1.47 interleukin-1beta regulatory function on the enzyme form from decidual macrophages Homo sapiens
3.1.1.47 interleukin-8 regulatory function on the enzyme form from decidual and monocyte-derived macrophages Homo sapiens
3.1.1.47 lipopolysaccharides regulatory function on the enzyme form from decidual macrophages, monocyte-derived macrophages, and HL-60 cells Homo sapiens
3.1.1.47 lipopolysaccharides regulatory function on the enzyme form from Kupffer cells, plasma, lung, liver, spleen, bile, kidney, thymus, peritoneal macrophages, and peripheral leukocytes Rattus norvegicus
3.1.1.47 lyso-platelet-activating factor regulatory function on the enzyme form from hepatocytes Rattus norvegicus
3.1.1.47 tumor growth factor-beta regulatory function on the enzyme form from HL-60 cells Homo sapiens
3.1.1.47 tumor necrosis factor-alpha regulatory function on the enzyme form from decidual macrophages Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.47 cytosol erythrocyte isozyme Homo sapiens 5829
-
3.1.1.47 extracellular
-
 Mus musculus
-
-
3.1.1.47 extracellular
-
 Oryctolagus cuniculus
-
-
3.1.1.47 extracellular plasma enzyme type, secretion, physiological functions, overview Homo sapiens
-
-
3.1.1.47 extracellular plasma enzyme type, secretion, physiological functions, overview Rattus norvegicus
-
-
3.1.1.47 extracellular plasma enzyme type, secretion, physiological functions, overview Cricetinae
-
-
3.1.1.47 intracellular 4 isozymes, i.e. isozyme Ia, Ib, II, and the erythrocyte form, physiological functions, overview Homo sapiens 5622
-
3.1.1.47 intracellular 4 isozymes, i.e. isozyme Ia, Ib, II, and the erythrocyte form, physiological functions, overview Rattus norvegicus 5622
-
3.1.1.47 intracellular 4 isozymes, i.e. isozyme Ia, Ib, II, and the erythrocyte form, physiological functions, overview Cricetinae 5622
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.47 25000
-
 2 * 25000, erythrocyte isozyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Homo sapiens i.e. platelet-activation factor, hydrolysis of sn-2 ester bond of platelet-activating factor PAF and related inflammatory phospholipids, attenuation of their bioactivity, the beta-subunit of intracellular isozyme type II is encoded by gene LIS1, mutations of which cause Miller-Dieker lissencephaly 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Cricetinae i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibits the initiation of inflammation processes 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Mus musculus i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Rattus norvegicus i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Oryctolagus cuniculus i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O Mus musculus
-
 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O Homo sapiens
-
 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O Rattus norvegicus
-
 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O Oryctolagus cuniculus
-
 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O Cricetinae
-
 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 additional information Homo sapiens enzyme level in vivo is linked to the LDL-level, physiological functions of isozymes, overview, the beta-subunit of isozyme Ib interacts with tubulin and with microtubule-associated proteins ?
-
 ?
3.1.1.47 additional information Mus musculus physiological functions of isozymes, overview ?
-
 ?
3.1.1.47 additional information Rattus norvegicus physiological functions of isozymes, overview ?
-
 ?
3.1.1.47 additional information Oryctolagus cuniculus physiological functions of isozymes, overview ?
-
 ?
3.1.1.47 additional information Cricetinae physiological functions of isozymes, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Cricetinae
-
-
-
3.1.1.47 Homo sapiens
-
 1 extracellular, secreted plasma enzyme form and an intracellular form, devided into 4 isozyme types, differing in their primary sequences, tissue localizations, subunit compositions, and substrate preferences
-
3.1.1.47 Mus musculus
-
-
-
3.1.1.47 Oryctolagus cuniculus
-
-
-
3.1.1.47 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.47 the erythrocyte isozyme from the soluble fraction of erythrocytes Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.47 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate the catalytic triad of the extracellular plasma enzyme form is of the alpha/beta-hydrolase type Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 bile
-
 Rattus norvegicus
-
3.1.1.47 brain
-
 Homo sapiens
-
3.1.1.47 brain
-
 Rattus norvegicus
-
3.1.1.47 erythrocyte erythrocyte isozyme Homo sapiens
-
3.1.1.47 Hep-G2 cell
-
 Homo sapiens
-
3.1.1.47 hepatocyte
-
 Rattus norvegicus
-
3.1.1.47 HL-60 cell
-
 Homo sapiens
-
3.1.1.47 kidney
-
 Rattus norvegicus
-
3.1.1.47 Kupffer cell
-
 Rattus norvegicus
-
3.1.1.47 leukocyte peripheral Rattus norvegicus
-
3.1.1.47 liver
-
 Homo sapiens
-
3.1.1.47 liver
-
 Rattus norvegicus
-
3.1.1.47 lung
-
 Rattus norvegicus
-
3.1.1.47 macrophage peritoneal Rattus norvegicus
-
3.1.1.47 macrophage decidual and monocyte-derived Homo sapiens
-
3.1.1.47 plasma
-
 Oryctolagus cuniculus
-
3.1.1.47 plasma
-
 Cricetinae
-
3.1.1.47 plasma plasma isozyme is not associated with low-density lipoprotein LDL, but with high-density lipoprotein HDL Mus musculus
-
3.1.1.47 plasma plasma isozyme is not associated with low-density lipoprotein LDL, but with high-density lipoprotein HDL Rattus norvegicus
-
3.1.1.47 plasma plasma isozyme, two third or more of the enzymatic activity is associated with low-density lipoprotein LDL, involving Trp115, Leu116, and Tyr205, the remainder is associated with high-density lipoprotein HDL Homo sapiens
-
3.1.1.47 spleen
-
 Rattus norvegicus
-
3.1.1.47 thymus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Mus musculus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Rattus norvegicus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Oryctolagus cuniculus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Cricetinae 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, hydrolysis of sn-2 ester bond of platelet-activating factor PAF and related inflammatory phospholipids, attenuation of their bioactivity, the beta-subunit of intracellular isozyme type II is encoded by gene LIS1, mutations of which cause Miller-Dieker lissencephaly Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibits the initiation of inflammation processes Cricetinae 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes Mus musculus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes Rattus norvegicus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes Oryctolagus cuniculus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, hydrolysis of sn-2 ester bond of platelet-activating factor PAF and related inflammatory phospholipids, no activity with the erythrocyte isozyme Homo sapiens 1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Homo sapiens 1-O-alkyl-sn-glycero-3-phosphoethanolamine + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
-
 Mus musculus 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
-
 Homo sapiens 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
-
 Rattus norvegicus 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
-
 Oryctolagus cuniculus 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
-
 Cricetinae 1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
 ?
3.1.1.47 additional information substrate specificity of the enzyme forms and isoenzyme types Mus musculus ?
-
 ?
3.1.1.47 additional information substrate specificity of the enzyme forms and isoenzyme types Rattus norvegicus ?
-
 ?
3.1.1.47 additional information substrate specificity of the enzyme forms and isoenzyme types Oryctolagus cuniculus ?
-
 ?
3.1.1.47 additional information substrate specificity of the enzyme forms and isoenzyme types Cricetinae ?
-
 ?
3.1.1.47 additional information substrate specificity of the enzyme forms and isoenzyme types, the isozyme Ib interacts with some plekstrin domains in vitro Homo sapiens ?
-
 ?
3.1.1.47 additional information enzyme level in vivo is linked to the LDL-level, physiological functions of isozymes, overview, the beta-subunit of isozyme Ib interacts with tubulin and with microtubule-associated proteins Homo sapiens ?
-
 ?
3.1.1.47 additional information physiological functions of isozymes, overview Mus musculus ?
-
 ?
3.1.1.47 additional information physiological functions of isozymes, overview Rattus norvegicus ?
-
 ?
3.1.1.47 additional information physiological functions of isozymes, overview Oryctolagus cuniculus ?
-
 ?
3.1.1.47 additional information physiological functions of isozymes, overview Cricetinae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.47 dimer 2 * 25000, erythrocyte isozyme, SDS-PAGE Homo sapiens
3.1.1.47 monomer intracellular isozyme II, and plasma enzyme form Mus musculus
3.1.1.47 monomer intracellular isozyme II, and plasma enzyme form Homo sapiens
3.1.1.47 monomer intracellular isozyme II, and plasma enzyme form Rattus norvegicus
3.1.1.47 monomer intracellular isozyme II, and plasma enzyme form Oryctolagus cuniculus
3.1.1.47 monomer intracellular isozyme II, and plasma enzyme form Cricetinae
3.1.1.47 trimer the intracellular G-protein-like isozyme Ib consists of two catalytic subunits alpha1 and alpha2 and one regulatory subunit beta Mus musculus
3.1.1.47 trimer the intracellular G-protein-like isozyme Ib consists of two catalytic subunits alpha1 and alpha2 and one regulatory subunit beta Homo sapiens
3.1.1.47 trimer the intracellular G-protein-like isozyme Ib consists of two catalytic subunits alpha1 and alpha2 and one regulatory subunit beta Rattus norvegicus
3.1.1.47 trimer the intracellular G-protein-like isozyme Ib consists of two catalytic subunits alpha1 and alpha2 and one regulatory subunit beta Oryctolagus cuniculus
3.1.1.47 trimer the intracellular G-protein-like isozyme Ib consists of two catalytic subunits alpha1 and alpha2 and one regulatory subunit beta Cricetinae

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 PAF acetylhydrolase
-
 Mus musculus
3.1.1.47 PAF acetylhydrolase
-
 Homo sapiens
3.1.1.47 PAF acetylhydrolase
-
 Rattus norvegicus
3.1.1.47 PAF acetylhydrolase
-
 Oryctolagus cuniculus
3.1.1.47 PAF acetylhydrolase
-
 Cricetinae
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Mus musculus
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Homo sapiens
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Rattus norvegicus
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Oryctolagus cuniculus
3.1.1.47 platelet-activating factor acetylhydrolase
-
 Cricetinae