EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.22 | 1,10-phenanthroline | half-maximal inhibition at 1.8 mM, competitive and reversible inhibition is reversed by ZnCl2, increases 20fold the inhibition by EDTA | Tenebrio molitor | |
3.4.11.22 | 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide | inactivation by modification of pK 5.8 carboxylate, presence arginine hydroxamate decreases inhibitory potency, hydroxylamine does not recover enzyme activity | Tenebrio molitor | |
3.4.11.22 | arginine hydroxamate | competitive | Tenebrio molitor | |
3.4.11.22 | bestatin | competitive | Tenebrio molitor | |
3.4.11.22 | crystal delta-endotoxin from Bacillus thuringiensis | - |
Tenebrio molitor | |
3.4.11.22 | diethyldicarbonate | inactivation by modification of an imidazole, presence of arginine hydroxamate decreases inhibitory potency, hydroxylamine partially recovers enzyme activity after inactivation | Tenebrio molitor | |
3.4.11.22 | EDTA | inactivation, is affected by pH and temperature, metal binding of at least one deprotonated imidazole group is involved, presence of arginine hydroxamate decreases inhibitory potency, increased by 1,10-phenanthroline | Tenebrio molitor | |
3.4.11.22 | Methionine hydroxamate | competitive | Tenebrio molitor | |
3.4.11.22 | additional information | influence of inhibitors on each other, overview, no inhibition by 4-mercuribenzoate, isoamylalcohol and NaF | Tenebrio molitor | |
3.4.11.22 | Phenylglyoxal | - |
Tenebrio molitor | |
3.4.11.22 | Tetranitromethane | changes the Km of the enzyme without affecting Vmax by modifying a phenol group, presence arginine hydroxamate decreases inhibitory potency | Tenebrio molitor |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.11.22 | additional information | - |
additional information | kinetics and thermodynamics | Tenebrio molitor |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.11.22 | membrane | - |
Tenebrio molitor | 16020 | - |
3.4.11.22 | microvillus | - |
Tenebrio molitor | 5902 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.22 | additional information | metallopeptidase | Tenebrio molitor |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.11.22 | Tenebrio molitor | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.11.22 | - |
Tenebrio molitor |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.4.11.22 | Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates | catalysis depends on a catalytic metal, a carboxylate and a protonated imidazole group, whereas substrate binding requires one phenol and one carboxylate group | Tenebrio molitor |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.11.22 | larva | - |
Tenebrio molitor | - |
3.4.11.22 | midgut | - |
Tenebrio molitor | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.22 | Leu-4-nitroanilide + H2O | - |
Tenebrio molitor | Leu + 4-nitroaniline | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.11.22 | Aminopeptidase III | - |
Tenebrio molitor |
3.4.11.22 | Aminopeptidase yscI | - |
Tenebrio molitor |
3.4.11.22 | Leucine aminopeptidase IV | - |
Tenebrio molitor |
3.4.11.22 | More | enzyme belongs to the peptidase family M18 | Tenebrio molitor |
3.4.11.22 | Yeast aminopeptidase I | - |
Tenebrio molitor |
EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.11.22 | 10 | 45 | - |
Tenebrio molitor |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.11.22 | 8 | - |
- |
Tenebrio molitor |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
3.4.11.22 | 5 | 8.3 | pH profile | Tenebrio molitor |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.11.22 | additional information | - |
additional information | inhibition kinetics | Tenebrio molitor | |
3.4.11.22 | 0.6 | - |
arginine hydroxamate | pH 7.8, 30°C | Tenebrio molitor | |
3.4.11.22 | 0.7 | - |
EDTA | pH 7.8, 37°C, in presence of 1,10-phenanthroline | Tenebrio molitor | |
3.4.11.22 | 1.2 | - |
1,10-phenanthroline | pH 7.8, 37°C | Tenebrio molitor |