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Literature summary extracted from

  • Stoeckel-Maschek, A.; Mrestani-Klaus, C.; Stiebitz, B.; Demuth, H.U.; Neubert, K.
    Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases (2000), Biochim. Biophys. Acta, 1479, 15-31.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.2 Ala-PSI[CS-N]-pyrrolidine competitive Homo sapiens
3.4.14.2 Ala-PSI[CS-N]-pyrrolidine competitive Sus scrofa
3.4.14.2 Ala-PSI[CS-N]-thiazolidine competitive Homo sapiens
3.4.14.2 Ala-PSI[CS-N]-thiazolidine competitive Sus scrofa
3.4.14.2 Ala-pyrrolidine competitive Homo sapiens
3.4.14.2 Ala-pyrrolidine competitive Sus scrofa
3.4.14.2 Ala-thiazolidine competitive Homo sapiens
3.4.14.2 Ala-thiazolidine competitive Sus scrofa
3.4.14.2 Ile-PSI[CS-N]-pyrrolidine competitive Homo sapiens
3.4.14.2 Ile-PSI[CS-N]-pyrrolidine competitive Sus scrofa
3.4.14.2 Ile-PSI[CS-N]-thiazolidine competitive Homo sapiens
3.4.14.2 Ile-PSI[CS-N]-thiazolidine competitive Sus scrofa
3.4.14.2 Ile-pyrrolidine competitive Homo sapiens
3.4.14.2 Ile-pyrrolidine competitive Sus scrofa
3.4.14.2 Ile-thiazolidine competitive Homo sapiens
3.4.14.2 Ile-thiazolidine competitive Sus scrofa
3.4.14.2 additional information isomerization of the thiazolidine derivatives Homo sapiens
3.4.14.2 additional information isomerization of the thiazolidine derivatives Sus scrofa
3.4.14.2 Phe-PSI[CS-N]-pyrrolidine competitive Homo sapiens
3.4.14.2 Phe-PSI[CS-N]-pyrrolidine competitive Sus scrofa
3.4.14.2 Phe-PSI[CS-N]-thiazolidine competitive Homo sapiens
3.4.14.2 Phe-PSI[CS-N]-thiazolidine competitive Sus scrofa
3.4.14.2 Phe-pyrrolidine competitive Homo sapiens
3.4.14.2 Phe-pyrrolidine competitive Sus scrofa
3.4.14.2 Phe-thiazolidine competitive Homo sapiens
3.4.14.2 Phe-thiazolidine competitive Sus scrofa
3.4.14.2 Val-PSI[CS-N]-pyrrolidine competitive Homo sapiens
3.4.14.2 Val-PSI[CS-N]-pyrrolidine competitive Sus scrofa
3.4.14.2 Val-PSI[CS-N]-thiazolidine competitive Homo sapiens
3.4.14.2 Val-PSI[CS-N]-thiazolidine competitive Sus scrofa
3.4.14.2 Val-pyrrolidine competitive Homo sapiens
3.4.14.2 Val-pyrrolidine competitive Sus scrofa
3.4.14.2 Val-thiazolidine competitive Homo sapiens
3.4.14.2 Val-thiazolidine competitive Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.2 0.25
-
 Gly-Pro-4-nitroanilide pH 5.5, 30°C Homo sapiens
3.4.14.2 0.59
-
 Gly-Pro-4-nitroanilide pH 5.5, 30°C Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.14.2 lysosomal
-
 Homo sapiens
-
-
3.4.14.2 lysosome
-
 Sus scrofa 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.2 Homo sapiens
-
-
-
3.4.14.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.2 kidney
-
 Sus scrofa
-
3.4.14.2 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.2 Gly-Pro-4-nitroanilide + H2O specific for proline Homo sapiens Gly-Pro + 4-nitroaniline
-
 ?
3.4.14.2 Gly-Pro-4-nitroanilide + H2O specific for proline Sus scrofa Gly-Pro + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.2 dipeptidyl peptidase II
-
 Homo sapiens
3.4.14.2 dipeptidyl peptidase II
-
 Sus scrofa
3.4.14.2 DP II
-
 Homo sapiens
3.4.14.2 DP II
-
 Sus scrofa
3.4.14.2 More enzyme belongs to the Pro-X carboxypeptidase family S28 Homo sapiens
3.4.14.2 More enzyme belongs to the Pro-X carboxypeptidase family S28 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.14.2 30
-
 assay at Homo sapiens
3.4.14.2 30
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.2 5.5
-
 assay at Homo sapiens
3.4.14.2 5.5
-
 assay at Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.14.2 0.00028
-
 Ala-PSI[CS-N]-thiazolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0006
-
 Phe-PSI[CS-N]-thiazolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.00065
-
 Ala-PSI[CS-N]-thiazolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.00066
-
 Val-PSI[CS-N]-thiazolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0009
-
 Val-PSI[CS-N]-thiazolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.00091
-
 Ile-PSI[CS-N]-thiazolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0011
-
 Ile-PSI[CS-N]-thiazolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0014
-
 Ala-PSI[CS-N]-pyrrolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0016
-
 Phe-thiazolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0032
-
 Phe-thiazolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0033
-
 Ala-PSI[CS-N]-pyrrolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0035
-
 Phe-PSI[CS-N]-thiazolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0044
-
 Ala-thiazolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0048
-
 Ile-PSI[CS-N]-pyrrolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.005
-
 Val-PSI[CS-N]-pyrrolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0052
-
 Ala-thiazolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0057
-
 Val-thiazolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0071
-
 Ile-thiazolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0073
-
 Phe-PSI[CS-N]-pyrrolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0077
-
 Val-thiazolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0082
-
 Val-PSI[CS-N]-pyrrolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0082
-
 Ile-thiazolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0101
-
 Ile-PSI[CS-N]-pyrrolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0116
-
 Phe-pyrrolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0139
-
 Phe-pyrrolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0159
-
 Phe-PSI[CS-N]-pyrrolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0218
-
 Ala-pyrrolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.023
-
 Ala-pyrrolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0247
-
 Ile-pyrrolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0259
-
 Val-pyrrolidine pH 5.5, 30°C Sus scrofa
3.4.14.2 0.0267
-
 Val-pyrrolidine pH 5.5, 30°C Homo sapiens
3.4.14.2 0.0302
-
 Ile-pyrrolidine pH 5.5, 30°C Homo sapiens