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Literature summary extracted from

  • Ryzhova, T.A.; Andreichuk, Y.V.; Domkin, V.D.
    Adenylosuccinate synthetase of the yeast Saccharomyces cerevisiae: purification and properties (1998), Biochemistry, 63, 650-656.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.4 5-amino-4-(N-succinocarboxamide)imidazole ribonucleotide
-
 Saccharomyces cerevisiae
6.3.4.4 5-amino-4-carbamoyl-imidazole ribonucleotide
-
 Saccharomyces cerevisiae
6.3.4.4 aspartate analogs
-
 Saccharomyces cerevisiae
6.3.4.4 hydroxylamine
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.4 0.16
-
 GTP
-
 Saccharomyces cerevisiae
6.3.4.4 1.7
-
 IMP
-
 Saccharomyces cerevisiae
6.3.4.4 6.7
-
 L-aspartate
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.4 GTP + IMP + L-aspartate Saccharomyces cerevisiae
-
 GDP + phosphate + adenylosuccinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.4 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.4
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.4 2'-dGTP + IMP + L-aspartate
-
 Saccharomyces cerevisiae 2'-dGDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 ddGTP + IMP + L-aspartate
-
 Saccharomyces cerevisiae ddGDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-aspartate
-
 Saccharomyces cerevisiae GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + ITP + L-aspartate
-
 Saccharomyces cerevisiae ?
-
 ?
6.3.4.4 ITP + IMP + L-aspartate
-
 Saccharomyces cerevisiae IDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 additional information ATP cannot be used as substrate instead of GTP Saccharomyces cerevisiae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.4.4 dimer
-
 Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
6.3.4.4 Adenylosuccinate synthetase
-
 Saccharomyces cerevisiae
6.3.4.4 AS-synthetase
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.4.4 35
-
-
 Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.4.4 7
-
-
 Saccharomyces cerevisiae