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Literature summary extracted from

  • Ally, N.; Whisstock, J.C.; Sieprawska-Lupa, M.; Potempa, J.; Le Bonniec, B.F.; Travis, J.; Pike, R.N.
    Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes (2003), Biochemistry, 42, 11693-11700.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.37 protein + H2O Porphyromonas gingivalis
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.37 Porphyromonas gingivalis
-
 isoforms HRgpA and RgpB, the first containing 4 amino acid changes compared to the latter, which are D281N, Y283S, P286S, and N331K that all map to the region surrounding the active site
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.37 fibrinogen A alpha-chain + H2O major cleavage site at position 22, all isoforms Porphyromonas gingivalis 28 kDa fragment + ? the 28 kDa fragment is the major product of isoform HRgpA ?
3.4.22.37 fibrinogen B beta-chain + H2O high activity of isoform HRgpA, which performs cleavage at 2 positions: 42 and 44 Porphyromonas gingivalis ?
-
 ?
3.4.22.37 additional information substrate specificity for the C-terminal position next to the cleavage site of the different enzyme forms, overview Porphyromonas gingivalis ?
-
 ?
3.4.22.37 protein + H2O
-
 Porphyromonas gingivalis peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.37 More molecular modeling of the catalytic domain structure of HRgpA based on the RgpB structure, isoforms HRgpA and RgpB, the first containing 4 amino acid changes compared to the latter, which are D281N, Y283S, P286S, and N331K that all map to the region surrounding the active site Porphyromonas gingivalis

Synonyms

EC Number Synonyms Comment Organism
3.4.22.37 Arginine-specific gingipain
-
 Porphyromonas gingivalis
3.4.22.37 gingipain-R
-
 Porphyromonas gingivalis
3.4.22.37 HRgpA
-
 Porphyromonas gingivalis
3.4.22.37 RgpB
-
 Porphyromonas gingivalis