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Literature summary extracted from

  • Halgand, F.; Wessel, P.M.; Laprevote, O.; Dumas, R.
    Biochemical and mass spectrometric evidence for quaternary structure modifications of plant threonine deaminase induced by isoleucine (2002), Biochemistry, 41, 13767-13773.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.1.19 expression in Escherichia coli Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.19 isoleucine allosteric effector inducing dimerization, inhibition is reversed by high concentrations of valine Arabidopsis thaliana

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.19 59567
-
2 * 59567, mass spectrometry, addition of isoleucine induces dimerization, tetrmerization is restored by addition of high valine concentration Arabidopsis thaliana
4.3.1.19 59567
-
4 * 59567, mass spectrometry Arabidopsis thaliana
4.3.1.19 140000
-
native PAGE, in the presence of the allosteric effector isoleucine Arabidopsis thaliana
4.3.1.19 268000
-
native PAGE, in the absence of allosteric effector Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.19 L-threonine Arabidopsis thaliana
-
2-oxobutanoate + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.19 Arabidopsis thaliana
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.3.1.19 recombinant threonine deaminase Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.19 L-threonine
-
Arabidopsis thaliana 2-oxobutanoate + NH3
-
?

Subunits

EC Number Subunits Comment Organism
4.3.1.19 dimer 2 * 59567, mass spectrometry, addition of isoleucine induces dimerization, tetrmerization is restored by addition of high valine concentration Arabidopsis thaliana
4.3.1.19 tetramer 4 * 59567, mass spectrometry Arabidopsis thaliana

Synonyms

EC Number Synonyms Comment Organism
4.3.1.19 TD
-
Arabidopsis thaliana
4.3.1.19 Threonine deaminase
-
Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
4.3.1.19 pyridoxal 5'-phosphate 1 molecule per monomer Arabidopsis thaliana