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Literature summary extracted from

  • Rudyak, S.G.; Brenowitz, M.; Shrader, T.E.
    Mg2+-linked oligomerization modulates the catalytic activity of the Lon (La) protease from Mycobacterium smegmatis (2001), Biochemistry, 40, 9317-9323.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.53 alpha-casein activates the enzyme Mycolicibacterium smegmatis
3.4.21.53 additional information stimulated by unfolded protein and supported by nonhydrolyzed nucleotide analogs> Mycolicibacterium smegmatis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.53 wild-type and S675A mutant expressed in Escherichia coli SGR9 Mycolicibacterium smegmatis

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.53 S675A constructed mutation of the active site region Mycolicibacterium smegmatis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.53 Urea
-
 Mycolicibacterium smegmatis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.53 Mg2+ activation, Mg2+ linked oligomerization modulates the catalytic activity Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.53 Mycolicibacterium smegmatis
-
-
-

Subunits

EC Number Subunits Comment Organism
3.4.21.53 hexamer
-
 Mycolicibacterium smegmatis
3.4.21.53 oligomer
-
 Mycolicibacterium smegmatis

Synonyms

EC Number Synonyms Comment Organism
3.4.21.53 lon (la) protease
-
 Mycolicibacterium smegmatis
3.4.21.53 lon protease
-
 Mycolicibacterium smegmatis

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.53 ATP
-
 Mycolicibacterium smegmatis