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Literature summary extracted from

  • Myers, D.P.; Jackson, L.K.; Ipe, V.G.; Murphy, G.E.; Phillips, M.A.
    Long-range interactions in the dimer interface of ornithine decarboxylase are important for enzyme function (2001), Biochemistry, 40, 13230-13236.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.17 expression in Escherichia coli Trypanosoma brucei

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.17 C114A 59% of wild-type activity Trypanosoma brucei
4.1.1.17 C360A 3% of wild-type activity Trypanosoma brucei
4.1.1.17 D137A 103% of wild-type activity Trypanosoma brucei
4.1.1.17 D361A 33% of wild-type activity Trypanosoma brucei
4.1.1.17 E36A 59% of wild-type activity Trypanosoma brucei
4.1.1.17 F170A 53% of wild-type activity Trypanosoma brucei
4.1.1.17 F397A 0.3% of wild-type activity Trypanosoma brucei
4.1.1.17 F400A 0.15% of wild-type activity Trypanosoma brucei
4.1.1.17 I291A 20% of wild-type activity Trypanosoma brucei
4.1.1.17 K141A 3% of wild-type activity Trypanosoma brucei
4.1.1.17 K169A 1% of wild-type activity Trypanosoma brucei
4.1.1.17 K294A 8% of wild-type activity Trypanosoma brucei
4.1.1.17 L330A 29% of wild-type activity Trypanosoma brucei
4.1.1.17 L363A 36% of wild-type activity Trypanosoma brucei
4.1.1.17 N398A 3% of wild-type activity Trypanosoma brucei
4.1.1.17 Q116A 67% of wild-type activity Trypanosoma brucei
4.1.1.17 S395A 6% of wild-type activity Trypanosoma brucei
4.1.1.17 T93A 61% of wild-type activity Trypanosoma brucei
4.1.1.17 V392A 10% of wild-type activity Trypanosoma brucei
4.1.1.17 W356A 17% of wild-type activity Trypanosoma brucei
4.1.1.17 Y317A 10% of wild-type activity Trypanosoma brucei
4.1.1.17 Y323A 0.4% of wild-type activity Trypanosoma brucei
4.1.1.17 Y331A 64% of wild-type activity Trypanosoma brucei
4.1.1.17 Y389A no activity Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.17 0.49
-
 L-ornithine
-
 Trypanosoma brucei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.17 L-ornithine Trypanosoma brucei
-
 putrescine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Trypanosoma brucei P07805
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.17 recombinant ODC Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 L-ornithine
-
 Trypanosoma brucei putrescine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.17 dimer ODC is an obligate homodimer Trypanosoma brucei

Synonyms

EC Number Synonyms Comment Organism
4.1.1.17 ODC
-
 Trypanosoma brucei

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.17 9.4
-
 L-ornithine
-
 Trypanosoma brucei

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.17 pyridoxal 5'-phosphate
-
 Trypanosoma brucei