Literature summary extracted from

Braxton, B.L.; Mullins, L.S.; Raushel, F.M.; Reinhart, G.D.
Allosteric dominance in carbamoyl phosphate synthetase (1999), Biochemistry, 38, 1394-1401.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
6.3.5.5	L-ornithine	effector on ATP synthesis reaction, when ornithine is bound to the enzyme, its activation dominates the actions of UMP and IMP	Escherichia coli

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.3.5.5	IMP	slight inhibition at 25°C	Escherichia coli
6.3.5.5	UMP	strong effect on ATP synthesis reaction	Escherichia coli

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.5.5	Escherichia coli	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.5.5	2 ATP + L-Gln + HCO3-	-	Escherichia coli	2 ADP + phosphate + L-Glu + carbamoyl phosphate	-	?
6.3.5.5	2 ATP + NH4+ + HCO3-	-	Escherichia coli	2 ADP + phosphate + carbamoyl phosphate	-	?

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Release 2023.1 (January 2023)