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Literature summary extracted from

  • Khan, A.; Connerton, I.F.; Cummings, N.J.; Hussain, S.; Noble, M.A.; Taylor, M.A.J.; Thomas, E.W.; Verma, C.; Brocklehurst, K.
    The kinetically influential ionizations of caricain D158N revealed by using 4,4'-dipyrimidyl disulfide as a reactivity probe (1998), Biochem. Soc. Trans., 26, S172.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.30 D158N altered ionization kinetics required for catalysis Carica papaya

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.30 additional information
-
 additional information kinetics of wild-type and D158N mutant Carica papaya

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.30 protein + H2O Carica papaya
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.30 Carica papaya
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.22.30 hydrolysis of proteins with broad specificity for peptide bonds, similar to those of papain and chymopapain residue E50 is part of the electrostatic switch required for catalytic activity, mechanism, possible role of D158 Carica papaya
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.30 protein + H2O
-
 Carica papaya peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.30 Papaya proteinase OMEGA
-
 Carica papaya