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Literature summary extracted from

  • Bertoldi, M.; Borri Voltattorni, C.
    Reaction of dopa decarboxylase with L-aromatic amino acids under aerobic and anaerobic conditions (2000), Biochem. J., 352, 533-538.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.28 expressed in Escherichia coli Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.28 0.035
-
 L-Dopa pH 7.5, 25°C, anaerobiosis Sus scrofa
4.1.1.28 0.038
-
 L-5-hydroxytryptophan pH 7.5, 25°C, anaerobiosis Sus scrofa
4.1.1.28 0.0703
-
 L-Dopa pH 7.5, 25°C, aerobiosis Sus scrofa
4.1.1.28 0.155
-
 L-5-hydroxytryptophan pH 7.5, 25°C, aerobiosis Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.28 L-tryptophan Sus scrofa
-
 tryptamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.28 Sus scrofa
-
 pig
-

Oxidation Stability

EC Number Oxidation Stability Organism
4.1.1.28 reaction specificity with D-aromatic amino acids does not change in presence or absence of O2, the reaction with L-aromatic amino acids seems to be affected by O2 Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.28 recombinant enzyme Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.28 L-5-hydroxytryptophan
-
 Sus scrofa 5-hydroxytryptamine + CO2
-
 ?
4.1.1.28 L-Dopa
-
 Sus scrofa dopamine + CO2
-
 ?
4.1.1.28 L-tryptophan
-
 Sus scrofa tryptamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.28 homodimer
-
 Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
4.1.1.28 DDC
-
 Sus scrofa
4.1.1.28 DOPA decarboxylase
-
 Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.28 0.99
-
 L-5-hydroxytryptophan pH 7.5, 25°C, anaerobiosis Sus scrofa
4.1.1.28 1.99
-
 L-5-hydroxytryptophan pH 7.5, 25°C, aerobiosis Sus scrofa
4.1.1.28 2.57
-
 L-Dopa pH 7.5, 25°C, anaerobiosis Sus scrofa
4.1.1.28 2.94
-
 L-5-hydroxytryptophan pH 7.5, 25°C, aerobiosis Sus scrofa
4.1.1.28 3 6 L-Dopa pH 7.5, 25°C, anaerobiosis Sus scrofa
4.1.1.28 3.13
-
 L-Dopa pH 7.5, 25°C, aerobiosis Sus scrofa
4.1.1.28 4.26
-
 L-Dopa pH 7.5, 25°C, aerobiosis Sus scrofa
4.1.1.28 6.08
-
 L-5-hydroxytryptophan pH 7.5, 25°C, anaerobiosis Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.28 pyridoxal 5'-phosphate
-
 Sus scrofa