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Literature summary extracted from
- Inhibition of Candida albicans secreted aspartic protease by a novel series of peptidomimetics, also active on the HIV-1 protease (2002), Biochem. Biophys. Res. Commun., 297, 1350-1353.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.23.24 | acetyl-Phe-Ile-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl | transition-state peptidomimetic TS-41 | Candida albicans |  |
| 3.4.23.24 | acetyl-Trp-Phe-psi[OH-OH]-Phe-Trp-acetyl | transition-state peptidomimetic TS-49 | Candida albicans | |
| 3.4.23.24 | acetyl-Trp-Ser-Phe-psi[OH-OH]-Phe-kynurenic acid | transition-state peptidomimetic TS-57 | Candida albicans | |
| 3.4.23.24 | acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl | transition-state peptidomimetic TS-43 | Candida albicans | |
| 3.4.23.24 | acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Val-acetyl | transition-state peptidomimetic TS-75 | Candida albicans | |
| 3.4.23.24 | acetyl-Trp-Val-Phe-psi[OH-OH]-Phe-Val-Trp-acetyl | transition-state peptidomimetic TS-42 | Candida albicans | |
| 3.4.23.24 | Arg-Ile-Phe-psi[CH2-NH]-Phe-Gln-Arg | transition-state peptidomimetic TS-2 | Candida albicans | |
| 3.4.23.24 | kynurenic acid-Dtg-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid | transition-state peptidomimetic TS-92 | Candida albicans | |
| 3.4.23.24 | kynurenic acid-Dtg-Phe-psi[OH-OH]-Phe-phenoxyacetic acid | transition-state peptidomimetic TS-63 | Candida albicans | |
| 3.4.23.24 | kynurenic acid-Thr-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid | transition-state peptidomimetic TS-93 | Candida albicans | |
| 3.4.23.24 | kynurenic acid-Thr-Phe-psi[OH-OH]-Phe-kynurenic acid | transition-state peptidomimetic TS-59 | Candida albicans | |
| 3.4.23.24 | kynurenic acid-Val-Phe-psi(S,R,S)[OH]-Phe-dimethylphenoxyacetic acid | transition-state peptidomimetic TS-94 | Candida albicans | |
| 3.4.23.24 | kynurenic acid-Val-Phe-psi(S,R,S)[OH]-Phe-Val-kynurenic acid | transition-state peptidomimetic TS-91 | Candida albicans | |
| 3.4.23.24 | kynurenic acid-Val-Phe-psi[OH-OH]-Phe-Val-kynurenic acid | best inhibitor; transition-state peptidomimetic TS-70 | Candida albicans | |
| 3.4.23.24 | Lys-Ile-Phe-psi[CH2-NH]-Phe-Gln-Arg | transition-state peptidomimetic TS-23 | Candida albicans | |
| 3.4.23.24 | t-butoxylcarbonyl-Phe-psi[OH-OH]-Phe-Dtg-phenoxyacetic acid | transition-state peptidomimetic TS-54 | Candida albicans | |
| 3.4.23.24 | t-butoxylcarbonyl-Phe-psi[OH-OH]-Phe-Glu-Phe-acetyl | transition-state peptidomimetic TS-53 | Candida albicans | |
| 3.4.23.24 | Trp-Ile-Phe-psi[CH2-NH]-Phe-Gln-Trp | transition-state peptidomimetic TS-10 | Candida albicans | |
| 3.4.23.24 | Xan-Dtg-Val-psi(S,R,S)[OH]-Val-Dtg-Xan | transition-state peptidomimetic TS-90 | Candida albicans | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.23.24 | 44000 | - |
SDS-PAGE | Candida albicans |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.24 | protein + H2O | Candida albicans | - |
hydrolyzed protein | - |
? | |
| 3.4.23.24 | protein + H2O | Candida albicans H12 | - |
hydrolyzed protein | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.24 | Candida albicans | - |
- |
- |
| 3.4.23.24 | Candida albicans H12 | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.23.24 | from the culture medium of a virulent strain | Candida albicans |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.24 | Arg-Glu-[5-(aminoethyl)aminonaphthalene sulfonate]-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys-[4'-dimethylaminoazobenzene-4-carboxylate]-Arg + H2O | - |
Candida albicans | ? | - |
? | |
| 3.4.23.24 | Arg-Glu-[5-(aminoethyl)aminonaphthalene sulfonate]-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys-[4'-dimethylaminoazobenzene-4-carboxylate]-Arg + H2O | - |
Candida albicans H12 | ? | - |
? | |
| 3.4.23.24 | Bovine serum albumin + H2O | - |
Candida albicans | Hydrolyzed bovine serum albumin | - |
? | |
| 3.4.23.24 | Bovine serum albumin + H2O | - |
Candida albicans H12 | Hydrolyzed bovine serum albumin | - |
? | |
| 3.4.23.24 | protein + H2O | - |
Candida albicans | hydrolyzed protein | - |
? | |
| 3.4.23.24 | protein + H2O | - |
Candida albicans H12 | hydrolyzed protein | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.23.24 | SAP2 | - |
Candida albicans |
| 3.4.23.24 | secreted aspartic protease | - |
Candida albicans |
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