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Literature summary extracted from

  • Borri Voltattorni, C.; Bertoldi, M.; Bianconi, S.; Deng, W.p.; Wong, K.; Kim, I.; Herbert, B.; Kirk, K.L.
    Behavior of fluorinated analogs of L-(3,4-dihydroxyphenyl)alanine and L-threo-(3,4-dihydroxyphenyl)serine as substrates for Dopa decarboxylase (2002), Biochem. Biophys. Res. Commun., 295, 107-111.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.1.1.28 synthesis preparation of valuable biochemical and diagnostic tools Sus scrofa

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.28 expressed in Escherichia coli Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.28 0.091
-
 L-Dopa pH 6.8, 25°C Sus scrofa
4.1.1.28 0.7
-
 6-fluoro-DOPA pH 6.8, 25°C Sus scrofa
4.1.1.28 0.95
-
 2-fluoro-DOPA pH 6.8, 25°C Sus scrofa
4.1.1.28 3.35
-
 5-fluoro-DOPA pH 6.8, 25°C Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.28 L-tryptophan Sus scrofa
-
 tryptamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.28 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.28 recombinant enzyme Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.28 2-fluoro-DOPA
-
 Sus scrofa ?
-
 ?
4.1.1.28 2-fluoro-L-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa 4-(2-aminoethyl)-3-fluorobenzene-1,2-diol + CO2
-
 ?
4.1.1.28 5-fluoro-DOPA
-
 Sus scrofa ?
-
 ?
4.1.1.28 5-fluoro-L-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa 5-(2-aminoethyl)-3-fluorobenzene-1,2-diol + CO2
-
 ?
4.1.1.28 6-fluoro-DOPA
-
 Sus scrofa ?
-
 ?
4.1.1.28 6-fluoro-L-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa 4-(2-aminoethyl)-5-fluorobenzene-1,2-diol + CO2
-
 ?
4.1.1.28 6-fluoro-threo-(3,4-dihydroxyphenyl)serine
-
 Sus scrofa 4-(2-aminoethyl)-5-fluorobenzene-1,2-diol + CO2
-
 ?
4.1.1.28 L-(3,4-dihydroxyphenyl)alanine
-
 Sus scrofa 4-(2-aminoethyl)benzene-1,2-diol + CO2
-
 ?
4.1.1.28 L-threo-(3,4-dihydroxyphenyl)serine
-
 Sus scrofa 4-[(2-hydroxyethyl)amino]benzene-1,2-diol + CO2
-
 ?
4.1.1.28 L-tryptophan
-
 Sus scrofa tryptamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.28 DDC
-
 Sus scrofa
4.1.1.28 DOPA decarboxylase
-
 Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.28 3 6 5-fluoro-DOPA pH 6.8, 25°C Sus scrofa
4.1.1.28 3.47
-
 5-fluoro-DOPA pH 6.8, 25°C Sus scrofa
4.1.1.28 5.2
-
 2-fluoro-DOPA pH 6.8, 25°C Sus scrofa
4.1.1.28 8.2
-
 6-fluoro-DOPA pH 6.8, 25°C Sus scrofa
4.1.1.28 9.1
-
 L-Dopa pH 6.8, 25°C Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.28 pyridoxal 5'-phosphate
-
 Sus scrofa