Literature summary extracted from

Bowe, A.E.; Finnegan, R.; Jan de Beur, S.M.; Cho, J.; Levine, M.A.; Kumar, R.; Schiavi, S.C.
FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate (2001), Biochem. Biophys. Res. Commun., 284, 977-981.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.24.B15	expression as V5-epitope tagged enzyme in an in vitro rabbit reticulocyte lysate system	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.24.B15	protein + H2O	Homo sapiens	enzyme is involved in pathology of oncogenic osteomalacia, X-linked hypophosphatemia, and autosomal dominant hypophosphatemic rickets	peptides	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.B15	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.B15	oncogenic osteomalacia cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.B15	protein + H2O	-	Homo sapiens	peptides	-	?
3.4.24.B15	protein + H2O	enzyme is involved in pathology of oncogenic osteomalacia, X-linked hypophosphatemia, and autosomal dominant hypophosphatemic rickets	Homo sapiens	peptides	-	?
3.4.24.B15	protein FGF-23 + H2O	recombinant wild-type substrate, but not the recombinant mutant FGF-23(R179Q)	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.B15	M13.091	Merops-ID	Homo sapiens
3.4.24.B15	PHEX	-	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
3.4.24.B15	37	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)