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Literature summary extracted from

  • Ko, S.; Eliot, A.C.; Kirsch, J.F.
    S-methylmethionine is both a substrate and an inactivator of 1-aminocyclopropane-1-carboxylate synthase (2004), Arch. Biochem. Biophys., 421, 85-90.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.14 S-methyl-L-methionine covalent inactivation after elimination of dimethylsulfide Malus domestica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.4.1.14 0.012
-
 (S,S)-S-adenosyl-L-methionine alpha,gamma-elimination Malus domestica
4.4.1.14 0.037
-
 (R,S)-S-adenosyl-L-methionine beta,gamma-elimination Malus domestica
4.4.1.14 1.4
-
 L-Vinylglycine alpha-ketobutyrate production Malus domestica
4.4.1.14 4.1
-
 S-methyl-L-methionine beta,gamma-elimination Malus domestica
4.4.1.14 35
-
 L-alanine transamination Malus domestica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.14 (R,S)-S-adenosyl-L-methionine Malus domestica
-
 vinylglycine + methylthioadenosine
-
 ?
4.4.1.14 (S,S)-S-adenosyl-L-methionine Malus domestica
-
 1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
 ?
4.4.1.14 L-alanine + pyridoxal 5'-phosphate Malus domestica
-
 pyruvate + pyridoxamine 5'-phosphate
-
 ?
4.4.1.14 S-methyl-L-methionine Malus domestica
-
 alpha-ketobutyrate + ammonia + dimethylsulfide
-
 ?
4.4.1.14 S-methyl-L-methionine + pyridoxal 5'-phosphate Malus domestica transamination reaction 4-dimethylsulfonium-2-oxobutyrate + pyridoxamine 5'-phosphate
-
 ?
4.4.1.14 vinylglycine Malus domestica
-
 alpha-ketobutyrate + ammonia
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.14 Malus domestica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.14 (R,S)-S-adenosyl-L-methionine
-
 Malus domestica vinylglycine + methylthioadenosine
-
 ?
4.4.1.14 (S,S)-S-adenosyl-L-methionine
-
 Malus domestica 1-aminocyclopropane-1-carboxylate + methylthioadenosine
-
 ?
4.4.1.14 L-alanine + pyridoxal 5'-phosphate
-
 Malus domestica pyruvate + pyridoxamine 5'-phosphate
-
 ?
4.4.1.14 S-methyl-L-methionine
-
 Malus domestica alpha-ketobutyrate + ammonia + dimethylsulfide
-
 ?
4.4.1.14 S-methyl-L-methionine beta,gamma elimination of dimethylsulfide to yield enzyme bound L-vinylglycine, which is subsequently converted to alpha-ketobutyrate and ammonia Malus domestica alpha-ketobutyrate + ammonia + dimethylsulfide
-
 ?
4.4.1.14 S-methyl-L-methionine + pyridoxal 5'-phosphate transamination reaction Malus domestica 4-dimethylsulfonium-2-oxobutyrate + pyridoxamine 5'-phosphate
-
 ?
4.4.1.14 vinylglycine
-
 Malus domestica alpha-ketobutyrate + ammonia
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.14 ACC synthase
-
 Malus domestica

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.4.1.14 0.0008
-
 S-methyl-L-methionine transamination Malus domestica
4.4.1.14 0.0016
-
 S-methyl-L-methionine inactivation Malus domestica
4.4.1.14 0.0025
-
 L-alanine transamination Malus domestica
4.4.1.14 0.004
-
 L-Vinylglycine inactivation Malus domestica
4.4.1.14 0.045
-
 S-methyl-L-methionine beta,gamma-elimination Malus domestica
4.4.1.14 0.079
-
 (R,S)-S-adenosyl-L-methionine beta,gamma-elimination Malus domestica
4.4.1.14 1.8
-
 L-Vinylglycine alpha-ketobutyrate production Malus domestica
4.4.1.14 9.2
-
 (S,S)-S-adenosyl-L-methionine alpha,gamma-elimination Malus domestica

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.14 pyridoxal 5'-phosphate
-
 Malus domestica