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Literature summary extracted from

  • Hsu, P.Y.; Tsai, A.L.; Wang, L.H.
    Identification of thromboxane synthase amino acid residues involved in heme-propionate binding (2000), Arch. Biochem. Biophys., 383, 119-127.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.5 expression in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
5.3.99.5 A408L 42% of wild-type activity Homo sapiens
5.3.99.5 A415V 82% of wild-type activity Homo sapiens
5.3.99.5 C480H no activity Homo sapiens
5.3.99.5 C480S no activity Homo sapiens
5.3.99.5 C480Y no activity Homo sapiens
5.3.99.5 E134D 35% of wild-type activity Homo sapiens
5.3.99.5 E135D 123% of wild-type activity Homo sapiens
5.3.99.5 E414D 39% of wild-type activity Homo sapiens
5.3.99.5 F409Y 42% of wild-type activity Homo sapiens
5.3.99.5 F411Y 38% of wild-type activity Homo sapiens
5.3.99.5 N110I no activity Homo sapiens
5.3.99.5 R137A 2% of wild-type activity Homo sapiens
5.3.99.5 R137K 5% of wild-type activity Homo sapiens
5.3.99.5 R410G 46% of wild-type activity Homo sapiens
5.3.99.5 R413K 1% of wild-type activity Homo sapiens
5.3.99.5 R478A no activity Homo sapiens
5.3.99.5 T412S 41% of wild-type activity Homo sapiens
5.3.99.5 V136A 69% of wild-type activity Homo sapiens
5.3.99.5 W133F 2% of wild-type activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.5 endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.5 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate i.e. TXA2 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.5 recombinant TXAS Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate i.e. TXA2 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.5 TXAS
-
 Homo sapiens