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Literature summary extracted from

  • Guan, X.; Diez, T.; Prasad, T.K.; Nikolau, B.J.; Wurtele, E.S.
    Geranoyl-CoA carboxylase: a novel biotin-containing enzyme in plants (1999), Arch. Biochem. Biophys., 362, 12-21.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.5 Avidin complete inhibition, prevented by incubation of avidin with biotin prior to its addition Zea mays

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.4.1.5 0.0084
-
 ATP
-
 Zea mays
6.4.1.5 0.064
-
 geranoyl-CoA
-
 Zea mays
6.4.1.5 0.58
-
 HCO3-
-
 Zea mays

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.5 plastid
-
 Zea mays 9536
-
6.4.1.5 plastid 84% of GCCase activity is recovered in plastids Daucus carota 9536
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.4.1.5 Mg2+ absolute requirement Zea mays

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.4.1.5 122000
-
 x * 122000, biotin-containing subunit, SDS-PAGE, Western blot analysis Zea mays

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.5 ATP + geranoyl-CoA + HCO3- Zea mays plays an important role in isoprenoid catabolism ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
 ?
6.4.1.5 ATP + geranoyl-CoA + HCO3- Glycine max plays an important role in isoprenoid catabolism ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
 ?
6.4.1.5 ATP + geranoyl-CoA + HCO3- Daucus carota plays an important role in isoprenoid catabolism ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.5 Daucus carota
-
-
-
6.4.1.5 Glycine max
-
-
-
6.4.1.5 Zea mays
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.5 184fold, from leaves Zea mays

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.5 additional information
-
 specific activities in different developing embryos, effect of cotyledon development and cell growth on GCCase activity Daucus carota
6.4.1.5 additional information
-
 specific activities in several tissues of 4 and 15 days old seedlings Glycine max
6.4.1.5 additional information
-
 specific activities in several tissues of 7 days old seedlings Zea mays
6.4.1.5 0.138
-
-
 Zea mays

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.5 ATP + geranoyl-CoA + HCO3- ATP-dependent carboxylation of the methyl group that is proximal to the carboxyl end of geranoyl-CoA Zea mays ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA formation of gamma-carboxygeranoyl-CoA ?
6.4.1.5 ATP + geranoyl-CoA + HCO3- ATP-dependent carboxylation of the methyl group that is proximal to the carboxyl end of geranoyl-CoA Glycine max ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA formation of gamma-carboxygeranoyl-CoA ?
6.4.1.5 ATP + geranoyl-CoA + HCO3- ATP-dependent carboxylation of the methyl group that is proximal to the carboxyl end of geranoyl-CoA Daucus carota ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA formation of gamma-carboxygeranoyl-CoA ?
6.4.1.5 ATP + geranoyl-CoA + HCO3- plays an important role in isoprenoid catabolism Zea mays ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
 ?
6.4.1.5 ATP + geranoyl-CoA + HCO3- plays an important role in isoprenoid catabolism Glycine max ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
 ?
6.4.1.5 ATP + geranoyl-CoA + HCO3- plays an important role in isoprenoid catabolism Daucus carota ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
-
 ?
6.4.1.5 additional information not: methylcrotonyl-CoA Zea mays ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.5 ? x * 122000, biotin-containing subunit, SDS-PAGE, Western blot analysis Zea mays

Synonyms

EC Number Synonyms Comment Organism
6.4.1.5 GCCase
-
 Zea mays
6.4.1.5 GCCase
-
 Glycine max
6.4.1.5 GCCase
-
 Daucus carota

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4.1.5 8.3
-
-
 Zea mays

pH Range

EC Number pH Minimum pH Maximum Comment Organism
6.4.1.5 additional information
-
 active over a broad pH-range Zea mays

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.5 biotin biotin-dependent enzyme Zea mays
6.4.1.5 biotin biotin-dependent enzyme Glycine max
6.4.1.5 biotin biotin-dependent enzyme Daucus carota