Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Faust, J.; Fuchs, P.; Wrenger, S.; Reinhold, D.; Stoeckel-Maschek, A.; Kaehne, T.; Ansorge, S.; Neubert, K.
    Dipeptidyl peptidase IV inhibitors with the N-terminal MXP sequence: structure-activity-relationships (2003), Adv. Exp. Med. Biol., 524, 175-179.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 human HIV-1 Ala2-Tat(1-9) peptide amino acid sequence MAPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Arg2-Tat(1-9) peptide amino acid sequence MRPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Asn2-Tat(1-9) peptide amino acid sequence MNPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Asp2-Tat(1-9) peptide amino acid sequence MDPVDPNIE, moderate inhibitor Sus scrofa
3.4.14.5 human HIV-1 Cys2-Tat(1-9) peptide amino acid sequence MCPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Gln2-Tat(1-9) peptide amino acid sequence MQPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Glu2-Tat(1-9) peptide amino acid sequence MEPVDPNIE, moderate inhibitor Sus scrofa
3.4.14.5 human HIV-1 Gly2-Tat(1-9) peptide amino acid sequence MGPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 His2-Tat(1-9) peptide amino acid sequence MHPVDPNIE, strong inhibitor Sus scrofa
3.4.14.5 human HIV-1 Ile2-Tat(1-9) peptide amino acid sequence MIPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Leu2-Tat(1-9) peptide amino acid sequence MLPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Lys2-Tat(1-9) peptide amino acid sequence MKPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Met2-Tat(1-9) peptide amino acid sequence MMPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Phe2-Tat(1-9) peptide amino acid sequence MFPVDPNIE, strong inhibitor Sus scrofa
3.4.14.5 human HIV-1 Pro2-Tat(1-9) peptide amino acid sequence MPPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Ser2-Tat(1-9) peptide amino acid sequence MSPVDPNIE Sus scrofa
3.4.14.5 human HIV-1 Tat(1-9) peptide amino acid sequence MDPVDPNIE, N-terminal peptide of the viral Tat protein, natural inhibitor, inhibits antigen-, anti-CD-3- and mitogen-induced activation of human T-cells Sus scrofa
3.4.14.5 human HIV-1 Thr2-Tat(1-9) peptide amino acid sequence MTPVDPNIE, weak inhibitor Sus scrofa
3.4.14.5 human HIV-1 Trp2-Tat(1-9) peptide amino acid sequence MWPVDPNIE, most effective Tat peptide inhibitor derivative Sus scrofa
3.4.14.5 human HIV-1 Tyr2-Tat(1-9) peptide amino acid sequence MYPVDPNIE, strong inhibitor Sus scrofa
3.4.14.5 human HIV-1 Val2-Tat(1-9) peptide amino acid sequence MVPVDPNIE Sus scrofa
3.4.14.5 interleukin-2 peptide Met-IL-2(1-9) amino acid sequence MAPTSSSTKK, weak inhibitor Sus scrofa
3.4.14.5 Met-(4-benzoyl-phenylalanine)-DPVDPNIE
-
 Sus scrofa
3.4.14.5 Met-(4-nitrophenyl-alanine)-DPVDPNIE strong inhibitor Sus scrofa
3.4.14.5 Met-(beta-(1-naphthyl)-alanine)-DPVDPNIE strong inhibitor Sus scrofa
3.4.14.5 Met-(beta-(2-naphthyl)-alanine)-DPVDPNIE strong inhibitor Sus scrofa
3.4.14.5 Met-(beta-(3-benzothienyl)-alanine)-DPVDPNIE strong inhibitor Sus scrofa
3.4.14.5 Met-(beta-(3-biphenyl)-alanine)-DPVDPNIE
-
 Sus scrofa
3.4.14.5 Met-(beta-(4-pyridyl)-alanine)-DPVDPNIE
-
 Sus scrofa
3.4.14.5 Met-GCSF(1-9) peptide GCSF is the granulocyte colony stimulating factor, weak inhibitor Sus scrofa
3.4.14.5 additional information the MWP sequence motif is important for inhibition Sus scrofa
3.4.14.5 Nepsilon-nitrobenzyloxycarbonyl-Lys-thiazolidide suppresses mitogen- and alloantigen-induced T-cell proliferation, B-cell differentiation, immunoglobulin secretion and modulates cytokine production Sus scrofa
3.4.14.5 thromboxane A2 receptor peptide TXA2-R(1-9) N-terminal MWP sequence motif MWPNGSSLG, strong inhibitor Sus scrofa
3.4.14.5 W2-interleukin-2 peptide Met-IL-2(1-9) amino acid sequence MWPTSSSTKK Sus scrofa
3.4.14.5 W2-Met-GCSF(1-9) peptide GCSF is the granulocyte colony stimulating factor Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.14.5 additional information Sus scrofa enzyme plays a key role in the regulation of differentiation and growth of lymphocytes ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 B-lymphocyte
-
 Sus scrofa
-
3.4.14.5 kidney
-
 Sus scrofa
-
3.4.14.5 macrophage
-
 Sus scrofa
-
3.4.14.5 T-lymphocyte
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 (Ala-Pro)2-rhodamine R110 + H2O
-
 Sus scrofa Ala-Pro + rhodamine R110
-
 ?
3.4.14.5 additional information enzyme plays a key role in the regulation of differentiation and growth of lymphocytes Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 CD26
-
 Sus scrofa
3.4.14.5 dipeptidyl peptidase IV
-
 Sus scrofa
3.4.14.5 DP IV
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.14.5 0.0000022
-
 human HIV-1 Trp2-Tat(1-9) peptide
-
 Sus scrofa