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Literature summary extracted from

  • Jorgensen, C.M.; Hammer, K.; Martinussen, J.
    CTP limitation increases expression of CTP synthase in Lactococcus lactis (2003), J. Bacteriol., 185, 6562-6574.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.2 additional information Lactococcus lactis CTP limitation increases expression of CTP synthase in Lactococcus lactis. At normal CTP concentrations a terminator is preferentially formed in the pyrG leader, thereby reducing expression of CTP synthase. At low CTP concentrations the RNA polymerase pauses at a stretch of C residues inthe pyrG leader, thereby allowing an antiterminator to form and transcription to proceed ?
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Organism

EC Number Organism UniProt Comment Textmining
6.3.4.2 Lactococcus lactis
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.2 ATP + UTP + NH4+
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 Lactococcus lactis ADP + phosphate + CTP
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6.3.4.2 additional information CTP limitation increases expression of CTP synthase in Lactococcus lactis. At normal CTP concentrations a terminator is preferentially formed in the pyrG leader, thereby reducing expression of CTP synthase. At low CTP concentrations the RNA polymerase pauses at a stretch of C residues inthe pyrG leader, thereby allowing an antiterminator to form and transcription to proceed Lactococcus lactis ?
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