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Literature summary extracted from
- Properties of phosphoenolpyruvate mutase, the first enzyme in the aminoethylphosphonate biosynthetic pathway in Trypanosoma cruzi (2003), J. Biol. Chem., 278, 22703-22708.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.4.2.9 | - |
Trypanosoma cruzi |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.4.2.9 | 0.008 | - |
Phosphonopyruvate | 25°C, pH 8.0 | Trypanosoma cruzi |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.4.2.9 | cytosol | - |
Trypanosoma cruzi | 5829 | - |
| 5.4.2.9 | particle-bound | large granule fraction | Trypanosoma cruzi | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.2.9 | Co2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
| 5.4.2.9 | Mg2+ | absolutely required | Trypanosoma cruzi | |
| 5.4.2.9 | Mg2+ | Km: 0.0084 mM | Trypanosoma cruzi | |
| 5.4.2.9 | Mg2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
| 5.4.2.9 | Mn2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
| 5.4.2.9 | additional information | no activation by Ca2+ | Trypanosoma cruzi | |
| 5.4.2.9 | Ni2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
| 5.4.2.9 | Zn2+ | divalent cation required, in decreasing order of activitation: Mg2+, Co2+, Mn2+, Zn2+, Ni2+ | Trypanosoma cruzi | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.2.9 | Trypanosoma cruzi | Q8T8D9 | expressed during epimastygote, trypomastigote, mammalian amastigote stage | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.4.2.9 | 54 | - |
25°C, pH 8.0 | Trypanosoma cruzi |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.2.9 | phosphoenolpyruvate | - |
Trypanosoma cruzi | 3-phosphonopyruvate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.4.2.9 | 8 | - |
- |
Trypanosoma cruzi |
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