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Literature summary extracted from

  • Morris, J.C.; Ping-Sheng, L.; Shen, T.Y.; Mensa-Wilmot, K.
    Glycan requirements of glycosylphosphatidylinositol phospholipase C from Trypanosoma brucei. Glucosaminylinositol derivatives inhibit phosphatidylinositol phospholipase C (1995), J. Biol. Chem., 270, 2517-2524.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.14 additional information no activation by aminoglycoside antibiotic geneticin (G418) Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.14 Glucosaminyl-alpha-1,6-2-deoxy-D-myo-inositol i.e. compound VP-615L, more effective than VP-606L Trypanosoma brucei
4.6.1.14 Glucosaminyl-alpha-1,6-D-myo-inositol i.e. compound VP-606L or 6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-D-myo-inositol Trypanosoma brucei
4.6.1.14 Glucosaminyl-alpha-1,6-D-myo-inositol 1,2-cyclic phosphate i.e. compound VP-601L, product inhibition Trypanosoma brucei
4.6.1.14 Glucosaminyl-alpha-1,6-D-myo-inositol 1-dodecylphosphonate i.e. compound VP-604L Trypanosoma brucei
4.6.1.14 Glucosaminyl-alpha-1,6-D-myo-inositol 1-hexylphosphonate i.e. compound VFT-2 Trypanosoma brucei
4.6.1.14 glucosaminyl-alpha-1,6-D-myo-inositol 1-phosphate i.e. compound VP-600L Trypanosoma brucei
4.6.1.14 Inositol 1-dodecylphosphonate i.e. compound VP-602L Trypanosoma brucei
4.6.1.14 Mannosyl-alpha-1,4-glucosaminyl-alpha-1,6-D-myo-inositol i.e. O-alpha-D-mannopyranosyl-1,4-O-2-amino-2-deoxy-alpha-D-glucopyranosyl-1,6-D-myo-inositol Trypanosoma brucei
4.6.1.14 additional information no inhibition by palmitate, myristate, phosphatidylethanolamine, inositol 1-phosphate, N-acetylglucosamine, ethanolamine, inositol, glucosamine, mannose, glucosaminyl-alpha-1,6-2-deoxy-D-myo-inositol 1-phosphate (i.e. VP-612L), glucosaminyl-alpha-1,6-2-deoxy-L-myo-inositol (i.e. VP-614L) Trypanosoma brucei
4.6.1.14 N-(N,N-Dimethylcarbamyl)-glucosaminyl-alpha-1,6-D-myo-inositol i.e. compound VC-109B, less effective than VP-606L Trypanosoma brucei
4.6.1.14 N-Acetylglucosaminyl-alpha-1,6-D-myo-inositol i.e. compound VC-105B, weak Trypanosoma brucei
4.6.1.14 phosphatidylcholine weak Trypanosoma brucei
4.6.1.14 phosphatidylglycerol
-
 Trypanosoma brucei
4.6.1.14 phosphatidylinositol
-
 Trypanosoma brucei
4.6.1.14 phosphatidylserine
-
 Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.14 Trypanosoma brucei
-
 protozoan parasite
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.14 additional information glucosaminyl(alpha1-, 6)inositol is the crucial glycan moiety for substrate recognition Trypanosoma brucei ?
-
 ?
4.6.1.14 phosphatidylinositol very poor substrate Trypanosoma brucei inositol 1,2-cyclic phosphate + inositol phosphate
-
 ?
4.6.1.14 variant-surface-glycoprotein
-
 Trypanosoma brucei 1,2-didecanoylglycerol + soluble variant-surface-glycoprotein i.e. 1,2-dimyristoylglycerol ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.14 37
-
 assay at Trypanosoma brucei