EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.14 | butanol | activation, 2% v/v, acidic enzyme form, not neutral enzyme form | Mus musculus | |
4.6.1.14 | deoxycholate | activation, 0.5-1 mg/ml, neutral enzyme form, not acidic enzyme form, inhibits above 1 mg/ml | Mus musculus | |
4.6.1.14 | additional information | 2 enzyme forms differing in pH-optima and response to stimulation by butanol and deoxycholate | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.14 | cetrimide | i.e. alkyltrimethylammonium bromide, 0.3 mg/ml, neutral enzyme form | Mus musculus | |
4.6.1.14 | deoxycholate | neutral enzyme form, above 1 mg/ml, activation at 0.5-1 mg/ml | Mus musculus | |
4.6.1.14 | EGTA | Ca2+ reverses, only acidic, not neutral enzyme form | Mus musculus | |
4.6.1.14 | additional information | no inhibition by Mn2+ | Mus musculus | |
4.6.1.14 | Nonidet P-40 | above 0.1% w/v, neutral enzyme form | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.6.1.14 | cytoplasmic membrane | neutral enzyme form | Mus musculus | - |
- |
4.6.1.14 | lysosome | predominantly acidic enzyme form | Mus musculus | 5764 | - |
4.6.1.14 | membrane | - |
Mus musculus | 16020 | - |
4.6.1.14 | additional information | subcellular localization in mouse brain membranes | Mus musculus | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.14 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.6.1.14 | brain | - |
Mus musculus | - |
4.6.1.14 | myelin | neutral enzyme form | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.14 | variant-surface-glycoprotein | highly specific | Mus musculus | 1,2-didecanoylglycerol + soluble variant-surface-glycoprotein | - |
? | |
4.6.1.14 | variant-surface-glycoprotein | isolated from Trypanosoma equiperdum BoTat-1 | Mus musculus | 1,2-didecanoylglycerol + soluble variant-surface-glycoprotein | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.6.1.14 | 37 | - |
assay at | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.6.1.14 | 4.5 | 5 | acidic enzyme form | Mus musculus |
4.6.1.14 | 6.5 | 7 | neutral enzyme form | Mus musculus |