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Literature summary extracted from
- Characterization of selenocysteine lyase in human tissues and its relationship to tissue selenium concentrations (1992), J. Trace Elem. Electrolytes Health Dis., 6, 189-194.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.16 | L-cysteine | noncompetitive | Homo sapiens |  |
| 4.4.1.16 | L-cysteine | noncompetitive | Sus scrofa | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.16 | 0.5 | - |
L-selenocysteine | - |
Homo sapiens | |
| 4.4.1.16 | 0.5 | - |
L-selenocysteine | - |
Sus scrofa | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.16 | L-selenocysteine + reduced acceptor | Homo sapiens | - |
selenide + L-alanine + acceptor | - |
? | |
| 4.4.1.16 | L-selenocysteine + reduced acceptor | Sus scrofa | - |
selenide + L-alanine + acceptor | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.4.1.16 | Homo sapiens | - |
- |
- |
| 4.4.1.16 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.4.1.16 | adrenal gland | - |
Homo sapiens | - |
| 4.4.1.16 | adrenal gland | - |
Sus scrofa | - |
| 4.4.1.16 | heart | - |
Homo sapiens | - |
| 4.4.1.16 | heart | - |
Sus scrofa | - |
| 4.4.1.16 | kidney | - |
Homo sapiens | - |
| 4.4.1.16 | kidney | - |
Sus scrofa | - |
| 4.4.1.16 | liver | - |
Homo sapiens | - |
| 4.4.1.16 | liver | - |
Sus scrofa | - |
| 4.4.1.16 | muscle | - |
Homo sapiens | - |
| 4.4.1.16 | muscle | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.4.1.16 | L-selenocysteine + reduced acceptor | - |
Homo sapiens | selenide + L-alanine + acceptor | - |
? | |
| 4.4.1.16 | L-selenocysteine + reduced acceptor | - |
Sus scrofa | selenide + L-alanine + acceptor | - |
? | |
| 4.4.1.16 | L-selenocysteine + reduced acceptor | - |
Homo sapiens | selenide + L-alanine + acceptor | H2Se detected as product | ? | |
| 4.4.1.16 | L-selenocysteine + reduced acceptor | - |
Sus scrofa | selenide + L-alanine + acceptor | H2Se detected as product | ? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.4.1.16 | pyridoxal 5'-phosphate | required | Homo sapiens | |
| 4.4.1.16 | pyridoxal 5'-phosphate | required | Sus scrofa | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.4.1.16 | 5.85 | - |
L-cysteine | - |
Homo sapiens | |
| 4.4.1.16 | 5.85 | - |
L-cysteine | - |
Sus scrofa | |
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