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Literature summary extracted from

  • Katcher, H.L.; Wallace, S.S.
    Characterization of Escherichia coli x-ray endonuclease, endonulease II (1983), Biochemistry, 22, 4071-4081.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.99.18 additional information no inhibition by N-ethylmaleimide Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.99.18 KCl stimulates Escherichia coli
4.2.99.18 KCl optimal concentration: 0.05-0.1 M, activity against apurinic and apyrimidinic sites, 50% inhibition at 0.02 and 0.12 M Escherichia coli
4.2.99.18 KCl optimal concentration: 0.10 M, activity against OsO4-sites, 50% inhibition at 0.05 and 0.15 M Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.99.18 25000
-
glycerol density gradient sedimentation Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.99.18 DNA Escherichia coli
-
fragments of DNA
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.2.99.18 Escherichia coli
-
X-ray endonuclease III
-
4.2.99.18 Escherichia coli
-
enzyme also has DNA N-glycosylase activity
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.99.18
-
Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.2.99.18 additional information
-
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.99.18 DNA
-
Escherichia coli fragments of DNA
-
?
4.2.99.18 DNA endonucleolytic activity against apurinic and apyrimidinic sites and a dose-dependent response to DNA that has been X-irradiated, UV-irradiated or treated with OsO4 Escherichia coli fragments of DNA
-
?
4.2.99.18 DNA cleaves the phosphodiester bond 3' to the apurinic/apyrimidinic site Escherichia coli fragments of DNA
-
?
4.2.99.18 additional information enzyme also has DNA N-glycosylase activity Escherichia coli ?
-
?

Subunits

EC Number Subunits Comment Organism
4.2.99.18 dimer 2 * 12000-14000, SDS-PAGE Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
4.2.99.18 X-ray endonuclease III
-
Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.99.18 7
-
activity against OsO4-treated DNA Escherichia coli
4.2.99.18 7.5
-
sharp optimum, activity against apurinic and apyrimidinic sites Escherichia coli

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.2.99.18 6.2 8.1 pH 6.2 and pH 8.1: 50% of activity maximum, activity against OsO4-treated DNA Escherichia coli
4.2.99.18 7.2 7.8 pH 7.2 and pH 7.8: 50% of activity maximal, activity against apyrimidinic and apurinic sites Escherichia coli