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Literature summary extracted from

  • Nes, I.F.
    Purification and properties of a mouse-cell DNA-repair endonuclease which recognizes lesions in DNA induced byy ultraviolet light, depurination, gamma-rays and OsO4 treatment (1980), Eur. J. Biochem., 112, 161-168.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.99.18 KCl optimal concentration: 100 mM Mus musculus
4.2.99.18 additional information presence of divalent cations does not stimulate the activity Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.99.18 28000
-
 gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.99.18 DNA Mus musculus
-
 fragments of DNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.99.18 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.99.18 117fold Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.99.18 MPC-11 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.99.18 DNA
-
 Mus musculus fragments of DNA
-
 ?
4.2.99.18 DNA enzyme recognizes apurinic and apyrimidinic sites induced by acid and gamma-rays, as well as lesions which are introduced into DNA by UV irradiation and OsO4 Mus musculus fragments of DNA
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.2.99.18 40
-
 half-life: 3.5 min Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.99.18 7.5 8.7
-
 Mus musculus