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Literature summary extracted from

  • Shi, G.P.; Munger, J.S.; Meara, J.P.; Rich, D.H.; Chapman, H.A.
    Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease (1992), J. Biol. Chem., 267, 7258-7262.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.27 Benzyloxycarbonyl-Phe-Phe-CHN2 0.001 mM, 98% inhibition Homo sapiens
3.4.22.27 benzyloxycarbonyl-Tyr-Ala-CHN2 0.001 mM, 88% inhibition Homo sapiens
3.4.22.27 benzyloxycarbonyl-Tyr-Tyr(O-butyl)-CHN2 1 mM, 78% inhibition Homo sapiens
3.4.22.27 cystatin 0.001 mM, complete inhibition Homo sapiens
3.4.22.27 E-64 0.001 mM, 96% inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.27 additional information Homo sapiens the enzyme may contribute to the contact-dependent elastase activity of live human alveolar macrophages ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.27 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.27 proteolytic modification the cDNA predicts a 331-amino acid prepro-cathepsin S Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.27 alveolar macrophage
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.27 additional information the enzyme may contribute to the contact-dependent elastase activity of live human alveolar macrophages Homo sapiens ?
-
 ?