Literature summary extracted from

Shindo, K.; Suzuki, H.; Okuda, T.
Paecilopeptin, a new cathepsin S inhibitor produced by Paecilomyces carneus (2002), Biosci. Biotechnol. Biochem., 66, 2444-2448.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.22.27	E64	64 nM	Homo sapiens
3.4.22.27	leupeptin	5.2 nM	Homo sapiens
3.4.22.27	paecilopeptin	i.e. acetyl-Leu-Val-CHO, IC50: 21 nM	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.27	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.22.27	benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin	-	?

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.4.22.27	0.000021	-	i.e. acetyl-Leu-Val-CHO, IC50: 21 nM	Homo sapiens	paecilopeptin

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Release 2023.1 (January 2023)