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Literature summary extracted from

  • Pai J.T.; Brown M.S.; Goldstein J.L.
    Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins (1996), Proc. Natl. Acad. Sci. USA, 93, 5437-5442.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.60
-
 Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.60 cytosol
-
 Mesocricetus auratus 5829
-
3.4.22.60 plasma membrane juxtamembrane structures Mesocricetus auratus 5886
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.60 Mesocricetus auratus P55214
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.22.60 proteolytic modification enzyme is synthesized as an inactive 30000-35000 Da precursor and is thought to be cleaved during apoptosis to generate active fragments of 20000 Da and 10000 Da Mesocricetus auratus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.60
-
 Mesocricetus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.60 liver
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.60 poly(ADP-ribose) polymerase + H2O
-
 Mesocricetus auratus ?
-
 ?
3.4.22.60 sterol regulatory element binding protein-2 + H2O SREBP-2 is sterol regulatory element binding protein-2 Mesocricetus auratus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.60 6.5
-
 cleavage of sterol regulatory element binding protein Mesocricetus auratus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.22.60 6 7 pH 6.0: about 35% of maximal activity, pH 7.0: about 15% of maximal activity, cleavage of sterol regulatory element binding protein Mesocricetus auratus