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Literature summary extracted from

  • Barrett, A.J.
    Leukocyte elastase (1981), Methods Enzymol., 80, 581-588.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.37 Alpha1-proteinase inhibitor
-
 Homo sapiens
3.4.21.37 alpha2-Macroglobulin
-
 Homo sapiens
3.4.21.37 elasnin
-
 Homo sapiens
3.4.21.37 Elastatinal
-
 Homo sapiens
3.4.21.37 Kunitz inhibitor
-
 Homo sapiens
3.4.21.37 long-chain fatty acids
-
 Homo sapiens
3.4.21.37 methoxysuccinyl-Ala-Ala-Pro-Val-CH2Cl
-
 Homo sapiens
3.4.21.37 ovomucoid turkey ovomucoid Homo sapiens
3.4.21.37 phenylmethylsulfonyl fluoride
-
 Homo sapiens
3.4.21.37 polysaccharide sulfates
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.37 azurophil granule
-
 Homo sapiens 42582
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.37 additional information Homo sapiens the enzyme may be involved in a number of important disease states. Including the pulmonary emphysema associated with a hereditary deficiency of alpha1-proteinase inhibitor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.37 Canis lupus familiaris
-
-
-
3.4.21.37 Equus caballus
-
-
-
3.4.21.37 Homo sapiens
-
-
-
3.4.21.37 Oryctolagus cuniculus
-
-
-
3.4.21.37 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.37 glycoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.37
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.37 leukocyte neutrophil leukocytes Homo sapiens
-
3.4.21.37 polymorphonuclear cell
-
 Homo sapiens
-
3.4.21.37 polymorphonuclear cell
-
 Sus scrofa
-
3.4.21.37 polymorphonuclear cell
-
 Oryctolagus cuniculus
-
3.4.21.37 polymorphonuclear cell
-
 Canis lupus familiaris
-
3.4.21.37 polymorphonuclear cell
-
 Equus caballus
-
3.4.21.37 spleen
-
 Homo sapiens
-
3.4.21.37 synovial membrane
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.4.21.37 -20°C, 0.5 M pyridine acetate buffer, pH 5.3, stable for years Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.37 Cartilage proteoglycan + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.37 Collagen + H2O type I, II, III, and IV Homo sapiens ?
-
 ?
3.4.21.37 Elastin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.37 Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.37 methoxysuccinyl-Ala-Ala-Pro-Val-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens methoxysuccinyl-Ala-Ala-Pro-Val + 7-amino-4-methylcoumarin
-
 ?
3.4.21.37 additional information the enzyme may be involved in a number of important disease states. Including the pulmonary emphysema associated with a hereditary deficiency of alpha1-proteinase inhibitor Homo sapiens ?
-
 ?
3.4.21.37 oxidized B chain of insulin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.37 tert-butyloxycarbonyl-Ala-4-nitrophenyl ester + H2O
-
 Homo sapiens tert-butyloxycarbonyl-Ala + 4-nitrophenol
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.37 8.5
-
-
 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.21.37 Homo sapiens
-
 9.15 8.77