EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.119 | antipain | - |
Mus musculus | |
3.4.21.119 | benzamidine | - |
Mus musculus | |
3.4.21.119 | leupeptin | - |
Mus musculus | |
3.4.21.119 | additional information | little or no effect by the following protease inhibitors: PMSF, DFP, aprotinin, iodoacetamide, NEM, PCMBS, and E-64; no inhibition by EDTA and pepstatin A | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.21.119 | cytosol | - |
Mus musculus | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.119 | polypeptide + H2O | Mus musculus | - |
peptides | - |
? | |
3.4.21.119 | Prorenin + H2O | Mus musculus | inactive precursor | Renin + ? | product is an active enzyme | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.119 | Mus musculus | - |
female and male ICR mice, Balb/c mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.119 | kidney | low activity | Mus musculus | - |
3.4.21.119 | additional information | no activity in liver, brain, heart, and pancreas | Mus musculus | - |
3.4.21.119 | submandibular gland | highest activity | Mus musculus | - |
3.4.21.119 | submandibular gland | enzyme regulation is parallel and similar to that of renin | Mus musculus | - |
3.4.21.119 | submandibular gland | larger amounts in male than female mice | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.119 | polypeptide + H2O | - |
Mus musculus | peptides | - |
? | |
3.4.21.119 | polypeptide + H2O | cleavage site at paired basic amino acid residues | Mus musculus | peptides | - |
? | |
3.4.21.119 | Prorenin + H2O | cleavage site at paired basic amino acid residues | Mus musculus | Renin + ? | - |
? | |
3.4.21.119 | Prorenin + H2O | murine or human origin substrate from Xenopus oocytes expression system | Mus musculus | Renin + ? | - |
? | |
3.4.21.119 | Prorenin + H2O | inactive precursor | Mus musculus | Renin + ? | product is an active enzyme | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.119 | More | enzyme is neither trypsin-like nor kallikrein | Mus musculus |
3.4.21.119 | prorenin-converting enzyme | - |
Mus musculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.21.119 | 37 | - |
assay at | Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.119 | 8 | 8.5 | - |
Mus musculus |