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Literature summary extracted from

  • Yousef, G.M.; Obiezu, C.V.; Luo, L.Y.; Black, M.H.; Diamandis, E.P.
    Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated (1999), Cancer Res., 59, 4252-4256.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.B12 androgens up-regulation of gene expression Homo sapiens
3.4.21.B12 progestins
-
 Homo sapiens
3.4.21.B12 progestins up-regulation of gene expression Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B12 DNA sequence determination and analysis, chromosome mapping and genomic organization Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B12 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?
3.4.21.B12 polypeptide + H2O Homo sapiens enzyme is regulated by steroid hormones peptides
-
 ?
3.4.21.B12 polypeptide + H2O Homo sapiens enzyme may be involved in the pathogenesis and/or progression of prostate, breast, and possibly other malgnancies peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B12 Homo sapiens Q9Y5K2 gene KLK-L1
-
3.4.21.B12 Homo sapiens Q9Y5K2 gene prostase
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B12 adrenal gland high expression level Homo sapiens
-
3.4.21.B12 bone marrow low expression level Homo sapiens
-
3.4.21.B12 brain low expression level, not in fetal brain Homo sapiens
-
3.4.21.B12 breast
-
 Homo sapiens
-
3.4.21.B12 BT-474 cell
-
 Homo sapiens
-
3.4.21.B12 cerebellum low expression level Homo sapiens
-
3.4.21.B12 colon medium expression level Homo sapiens
-
3.4.21.B12 lung low expression level Homo sapiens
-
3.4.21.B12 mammary gland medium expression level Homo sapiens
-
3.4.21.B12 additional information
-
 Homo sapiens
-
3.4.21.B12 additional information no expression in stomach, heart, spleen, placenta, liver, pancrease, kidney, skeletal muscle, small intestine Homo sapiens
-
3.4.21.B12 prostate
-
 Homo sapiens
-
3.4.21.B12 prostate high expression level Homo sapiens
-
3.4.21.B12 salivary gland low expression level Homo sapiens
-
3.4.21.B12 spinal cord medium expression level Homo sapiens
-
3.4.21.B12 testis high expression level Homo sapiens
-
3.4.21.B12 thymus low expression level Homo sapiens
-
3.4.21.B12 thyroid gland high expression level Homo sapiens
-
3.4.21.B12 trachea low expression level Homo sapiens
-
3.4.21.B12 uterus high expression level Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B12 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.21.B12 polypeptide + H2O enzyme is regulated by steroid hormones Homo sapiens peptides
-
 ?
3.4.21.B12 polypeptide + H2O enzyme may be involved in the pathogenesis and/or progression of prostate, breast, and possibly other malgnancies Homo sapiens peptides
-
 ?