Any feedback?
Literature summary extracted from
- Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond (1979), Eur. J. Biochem., 99, 239-246.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.19.6 | Cd2+ | - |
Sus scrofa |  |
| 3.4.19.6 | Chelating agents | - |
Sus scrofa | |
| 3.4.19.6 | CuSO4 | - |
Sus scrofa | |
| 3.4.19.6 | DTT | - |
Sus scrofa | |
| 3.4.19.6 | EDTA | - |
Sus scrofa | |
| 3.4.19.6 | Hg2+ | - |
Sus scrofa | |
| 3.4.19.6 | metal chelators | - |
Sus scrofa | |
| 3.4.19.6 | additional information | no inhibition by NEM; no inhibition by serine protease inhibitors; no inhition by 2-iodoacetamide | Sus scrofa | |
| 3.4.19.6 | Ni2+ | - |
Sus scrofa | |
| 3.4.19.6 | PCMB | - |
Sus scrofa | |
| 3.4.19.6 | ZnSO4 | - |
Sus scrofa | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.6 | 260000 | - |
gel filtration | Sus scrofa |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.19.6 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.19.6 | partial | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.19.6 | serum | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.19.6 | thyroliberin + H2O | cleavage at the pyroglutamyl-histidine bond | Sus scrofa | pyroglutamic acid + His-Pro-NH2 | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.6 | 40 | - |
- |
Sus scrofa |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.6 | 25 | 55 | about 70% of activity maximum at 25°C and 55°C | Sus scrofa |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.6 | 50 | - |
rapid and irreversible inactivation above | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.6 | 6.5 | 8 | - |
Sus scrofa |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.6 | 5.7 | 8.5 | pH 5.7: about 35% of maximal activity, pH 8.5: about 45% of maximal activity | Sus scrofa |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
