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Literature summary extracted from

  • Minami, M.; Ohishi, N.; Mutho, H.; Izumi, T.; Bito, H.; Wada, H.; Seyama, Y.; Toh, H.; Shimizu, T.
    Leukotriene A4 hydrolase is a zinc-containing aminopeptidase (1990), Biochem. Biophys. Res. Commun., 173, 620-626.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.3.2.6 medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Cavia porcellus
3.3.2.6 medicine the enzyme catalyses the hydrolysis of leukotriene A4 into the proinflammatory substance leukotriene B4 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 1,10-phenanthroline
-
 Homo sapiens
3.3.2.6 Leu-thiol
-
 Homo sapiens
3.3.2.6 PCMB
-
 Cavia porcellus
3.3.2.6 PCMB
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.3.2.6 Zinc recombinant enzyme: 0.7-1 mol of zinc/mol of enzyme Homo sapiens
3.3.2.6 Zinc small intestine: 0.99 mol of zinc/mol of enzyme Cavia porcellus
3.3.2.6 Zinc zinc protein Cavia porcellus
3.3.2.6 Zinc zinc protein Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O Homo sapiens biosynthesis of leukotriene B4 leukotriene B4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Cavia porcellus
-
-
-
3.3.2.6 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.3.2.6 leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Cavia porcellus
a
3.3.2.6 leukotriene A4 + H2O = leukotriene B4 bifunctional enzyme acting as an epoxide hydrolase and also as an aminopeptidase Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.6 small intestine
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Cavia porcellus leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?
3.3.2.6 leukotriene A4 + H2O biosynthesis of leukotriene B4 Homo sapiens leukotriene B4
-
 ?
3.3.2.6 additional information
-
 Cavia porcellus ?
-
 ?
3.3.2.6 additional information
-
 Homo sapiens ?
-
 ?