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Literature summary extracted from

  • Peumans, W.J.; Hao, Q.; Van Damme, E.J.
    Ribosome-inactivating proteins from plants: more than RNA N-glycosidases? (2001), FASEB J., 15, 1493-1506.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.2.22 agriculture potato plants expressing antiviral protein exhibit resistance against potato virus X, potato virus Y, and potato leafroll virus Phytolacca insularis
3.2.2.22 agriculture antiviral activity toward plant viruses Eranthis hyemalis
3.2.2.22 agriculture transgenic tobacco expressing trichosanthin is completely resistant against infection by turnip mosaic virus Trichosanthes sp.
3.2.2.22 medicine trichosanthin is a potent HIV-1 inhibitor Trichosanthes sp.
3.2.2.22 medicine TCS used as abortifacient in China Trichosanthes sp.
3.2.2.22 medicine DNA damaging activity of gelonin may be responsible for the elimination of the parasite 6 Kb extrachromosomal mitochondrial DNA of Plasmodium falciparum infected erythrocytes Suregada multiflora

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.22 MAP30 cloned and expressed in Escherichia coli Momordica charantia
3.2.2.22 potato plants expressing antiviral protein exhibits resistance against potato virus X, potato virus Y, and potato leafroll virus Phytolacca insularis
3.2.2.22 transgenic tobacco expressing trichosanthin is completely resistant against infection by turnip mosaic virus Trichosanthes sp.

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.2.2.22
-
 Ricinus communis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.2.22 60000
-
-
 Hordeum vulgare

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.22 rRNA + H2O Hordeum vulgare
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Saponaria officinalis
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Phytolacca americana
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Eranthis hyemalis
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Suregada multiflora
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Momordica charantia
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Phytolacca insularis
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Trichosanthes kirilowii
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Trichosanthes sp.
-
 ?
-
 ?
3.2.2.22 rRNA + H2O Abrus precatorius abrin plays an important role in the early development of immunology ?
-
 ?
3.2.2.22 rRNA + H2O Ricinus communis believed to protect the seeds they inhabit against plant-eating organisms like phytophagous invertebrates and herbivorous animals ?
-
 ?
3.2.2.22 rRNA + H2O Abrus precatorius believed to protect the seeds they inhabit against plant-eating organisms like phytophagous invertebrates and herbivorous animals ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.22 Abrus precatorius
-
 jequirity bean
-
3.2.2.22 Eranthis hyemalis
-
-
-
3.2.2.22 Hordeum vulgare
-
 barley
-
3.2.2.22 Momordica charantia
-
-
-
3.2.2.22 no activity in Arabidopsis thaliana
-
 does not express detectable amounts of RIPs or contain a sequence encoding a putative RIP
-
3.2.2.22 Phytolacca americana
-
 pokeweed, enzyme forms: PAP, PAP II, PAP-S
-
3.2.2.22 Phytolacca insularis
-
-
-
3.2.2.22 Ricinus communis
-
 castor bean
-
3.2.2.22 Saponaria officinalis
-
-
-
3.2.2.22 Suregada multiflora
-
-
-
3.2.2.22 Trichosanthes kirilowii
-
-
-
3.2.2.22 Trichosanthes sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.22 leaf
-
 Saponaria officinalis
-
3.2.2.22 leaf
-
 Phytolacca americana
-
3.2.2.22 leaf
-
 Trichosanthes sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.22 additional information
-
 Ricinus communis ?
-
 ?
3.2.2.22 additional information acts on tRNA and tobacco mosaic virus RNA Saponaria officinalis ?
-
 ?
3.2.2.22 poly(A) + H2O
-
 Saponaria officinalis adenine + ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Hordeum vulgare ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Ricinus communis ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Saponaria officinalis ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Phytolacca americana ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Abrus precatorius ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Eranthis hyemalis ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Suregada multiflora ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Momordica charantia ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Phytolacca insularis ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Trichosanthes kirilowii ?
-
 ?
3.2.2.22 rRNA + H2O
-
 Trichosanthes sp. ?
-
 ?
3.2.2.22 rRNA + H2O removes G4323 from rabbit reticulocyte, tobacco and yeast ribosomes Phytolacca americana ?
-
 ?
3.2.2.22 rRNA + H2O abrin plays an important role in the early development of immunology Abrus precatorius ?
-
 ?
3.2.2.22 rRNA + H2O believed to protect the seeds they inhabit against plant-eating organisms like phytophagous invertebrates and herbivorous animals Ricinus communis ?
-
 ?
3.2.2.22 rRNA + H2O believed to protect the seeds they inhabit against plant-eating organisms like phytophagous invertebrates and herbivorous animals Abrus precatorius ?
-
 ?
3.2.2.22 supercoiled double-stranded DNA + H2O
-
 Phytolacca americana nicked and linear forms of DNA
-
 ?
3.2.2.22 supercoiled double-stranded DNA + H2O
-
 Suregada multiflora nicked and linear forms of DNA
-
 ?
3.2.2.22 supercoiled double-stranded DNA + H2O
-
 Momordica charantia nicked and linear forms of DNA
-
 ?
3.2.2.22 supercoiled double-stranded DNA + H2O
-
 Trichosanthes sp. nicked and linear forms of DNA
-
 ?
3.2.2.22 supercoiled double-stranded DNA + H2O saporin-L1 depurinates DNA extensively and releases adenine from all adenine-containing polynucleotides Saponaria officinalis nicked and linear forms of DNA
-
 ?
3.2.2.22 supercoiled double-stranded DNA + H2O herring sperm DNA Saponaria officinalis nicked and linear forms of DNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.22 abrin
-
 Abrus precatorius
3.2.2.22 JIP60
-
 Hordeum vulgare
3.2.2.22 momordin I
-
 Momordica charantia
3.2.2.22 momordin II
-
 Momordica charantia
3.2.2.22 PAP
-
 Phytolacca americana
3.2.2.22 PAP-I
-
 Phytolacca americana
3.2.2.22 PAP-II
-
 Phytolacca americana
3.2.2.22 PAP-III
-
 Phytolacca americana
3.2.2.22 PAP-S
-
 Phytolacca americana
3.2.2.22 pokeweed antiviral protein
-
 Phytolacca americana
3.2.2.22 saporin-S6
-
 Saponaria officinalis