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Literature summary extracted from

  • Gonzalez, D.S.; Karaveg, K.; Vandersall-Nairn, A.S.; Lal, A.; Moremen, K.W.
    Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis (1999), J. Biol. Chem., 274, 21375-21386.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.209
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.209 1-deoxymannojirimycin 10% residual activity at 0.0002 mM Homo sapiens
3.2.1.209 EDTA Ca2+ restores Homo sapiens
3.2.1.209 EGTA complete loss of acvtivity at 0.1 mM, Ca2+ restores Homo sapiens
3.2.1.209 kifunensine 10% residual activity at 0.0002 mM Homo sapiens
3.2.1.209 additional information no inhibition by swainsonine Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.209 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.209 Homo sapiens Q9UKM7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.209 Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O
-
 Homo sapiens (Man)5GlcNAc + 4 D-mannose product is Man8GlcNAc ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.209 7
-
-
 Homo sapiens