BRENDA - Enzyme Database

Comparison of purified human and rabbit serum paraoxonases

Kuo, C.L.; La Du, B.N.; Drug Metab. Dispos. 23, 935-944 (1995)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.1.2
cardiolipin
stimulates
Oryctolagus cuniculus
3.1.1.2
dilauroyl phosphatidylcholine
stimulates
Homo sapiens
3.1.1.2
dimyristoyl phosphatidylcholine
stimulates
Homo sapiens
3.1.1.2
dimyristoyl phosphatidylcholine
stimulates
Oryctolagus cuniculus
3.1.1.2
dioleoyl phosphatidylcholine
stimulates
Homo sapiens
3.1.1.2
dioleoyl phosphatidylcholine
stimulates
Oryctolagus cuniculus
3.1.1.2
lecithin
stimulates
Homo sapiens
3.1.1.2
lecithin
stimulates
Oryctolagus cuniculus
3.1.1.2
lysolecithin
stimulates
Homo sapiens
3.1.1.2
lysolecithin
stimulates
Oryctolagus cuniculus
3.1.1.2
phosphatidylethanolamine
stimulates
Homo sapiens
3.1.1.2
phosphatidylethanolamine
stimulates
Oryctolagus cuniculus
3.1.1.2
phosphatidylglycerol
stimulates
Oryctolagus cuniculus
3.1.1.2
phosphatidylsenine
stimulates
Oryctolagus cuniculus
3.1.1.2
sphingomyelin
stimulates
Oryctolagus cuniculus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.2
EDTA
-
Oryctolagus cuniculus
3.1.1.2
EDTA
-
Homo sapiens
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.1.2
Ca2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites
Homo sapiens
3.1.1.2
Ca2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites
Oryctolagus cuniculus
3.1.1.2
Cd2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Homo sapiens
3.1.1.2
Cd2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Oryctolagus cuniculus
3.1.1.2
Zn2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Homo sapiens
3.1.1.2
Zn2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Oryctolagus cuniculus
3.1.8.1
Ca2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites
Homo sapiens
3.1.8.1
Ca2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites
Oryctolagus cuniculus
3.1.8.1
Cd2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Homo sapiens
3.1.8.1
Cd2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Oryctolagus cuniculus
3.1.8.1
Zn2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Homo sapiens
3.1.8.1
Zn2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Oryctolagus cuniculus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.1.1.2
39800
-
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE
Oryctolagus cuniculus
3.1.1.2
42300
-
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE
Oryctolagus cuniculus
3.1.8.1
additional information
-
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE
Oryctolagus cuniculus
3.1.8.1
40600
-
human serum contains one major species of PON monomer (44300 Da) and a minor species of PON monomer (40600 kDa)
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.1.2
Homo sapiens
-
-
-
3.1.1.2
Oryctolagus cuniculus
-
-
-
3.1.8.1
Homo sapiens
-
-
-
3.1.8.1
Oryctolagus cuniculus
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
3.1.1.2
glycoprotein
at least 2 N-linked sugar chains, contains sialic acid residues
Homo sapiens
3.1.1.2
glycoprotein
at least 2 N-linked sugar chains, contains sialic acid residues
Oryctolagus cuniculus
3.1.8.1
glycoprotein
at least 2 N-linked sugar chains, contains sialic acid residues
Homo sapiens
3.1.8.1
glycoprotein
at least 2 N-linked sugar chains, contains sialic acid residues
Oryctolagus cuniculus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.2
blood serum
contains A-type paraoxonase and B-type paraoxonase
Homo sapiens
-
3.1.1.2
blood serum
-
Oryctolagus cuniculus
-
3.1.8.1
blood serum
contains A-type paraoxonase and B-type paraoxonase
Homo sapiens
-
3.1.8.1
blood serum
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.2
1-naphthyl acetate + H2O
0.1% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
1-naphthol + acetate
-
-
-
?
3.1.1.2
1-naphthyl acetate + H2O
0.1% of the activity with phenyl acetate, A-type enzyme. 0.25% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
1-naphthol + acetate
-
-
-
?
3.1.1.2
2-naphthyl acetate + H2O
13.5% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
2-naphthol + acetate
-
-
-
?
3.1.1.2
2-naphthyl acetate + H2O
5.5% of the activity with phenyl acetate, A-type enzyme. 7% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
2-naphthol + acetate
-
-
-
?
3.1.1.2
2-nitrophenyl acetate + H2O
2.1% of the activity with phenyl acetate, A-type enzyme. 2% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
2-nitrophenol + acetate
-
-
-
?
3.1.1.2
2-nitrophenyl acetate + H2O
29% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
2-nitrophenol + acetate
-
-
-
?
3.1.1.2
4-nitrophenyl acetate + H2O
2.5% of the activity with phenyl acetate, A-type enzyme. 3.5% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
4-nitrophenol + acetate
-
-
-
?
3.1.1.2
4-nitrophenyl acetate + H2O
31% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
4-nitrophenol + acetate
-
-
-
?
3.1.1.2
phenyl acetate + H2O
-
646527
Homo sapiens
phenol + acetate
-
-
-
?
3.1.1.2
phenyl acetate + H2O
-
646527
Oryctolagus cuniculus
phenol + acetate
-
-
-
?
3.1.1.2
thiophenyl acetate + H2O
27% of the activity with phenyl acetate, A-type enzyme. 34% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
?
-
-
-
?
3.1.1.2
thiophenyl acetate + H2O
30.5% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
?
-
-
-
?
3.1.8.1
paraoxon + H2O
0.2% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
diethylphosphate + 4-nitrophenol
-
-
-
?
3.1.8.1
paraoxon + H2O
A-type paraoxonase shows 0.06% of the activity with phenyl acetate, B-type paraoxonase shows 2.5% of the activity with phenyl acetate
646527
Homo sapiens
diethylphosphate + 4-nitrophenol
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.1.2
cardiolipin
stimulates
Oryctolagus cuniculus
3.1.1.2
dilauroyl phosphatidylcholine
stimulates
Homo sapiens
3.1.1.2
dimyristoyl phosphatidylcholine
stimulates
Homo sapiens
3.1.1.2
dimyristoyl phosphatidylcholine
stimulates
Oryctolagus cuniculus
3.1.1.2
dioleoyl phosphatidylcholine
stimulates
Homo sapiens
3.1.1.2
dioleoyl phosphatidylcholine
stimulates
Oryctolagus cuniculus
3.1.1.2
lecithin
stimulates
Homo sapiens
3.1.1.2
lecithin
stimulates
Oryctolagus cuniculus
3.1.1.2
lysolecithin
stimulates
Homo sapiens
3.1.1.2
lysolecithin
stimulates
Oryctolagus cuniculus
3.1.1.2
phosphatidylethanolamine
stimulates
Homo sapiens
3.1.1.2
phosphatidylethanolamine
stimulates
Oryctolagus cuniculus
3.1.1.2
phosphatidylglycerol
stimulates
Oryctolagus cuniculus
3.1.1.2
phosphatidylsenine
stimulates
Oryctolagus cuniculus
3.1.1.2
sphingomyelin
stimulates
Oryctolagus cuniculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.2
EDTA
-
Oryctolagus cuniculus
3.1.1.2
EDTA
-
Homo sapiens
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.1.2
Ca2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites
Homo sapiens
3.1.1.2
Ca2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites
Oryctolagus cuniculus
3.1.1.2
Cd2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Homo sapiens
3.1.1.2
Cd2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Oryctolagus cuniculus
3.1.1.2
Zn2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Homo sapiens
3.1.1.2
Zn2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Oryctolagus cuniculus
3.1.8.1
Ca2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites
Homo sapiens
3.1.8.1
Ca2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites
Oryctolagus cuniculus
3.1.8.1
Cd2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Homo sapiens
3.1.8.1
Cd2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Oryctolagus cuniculus
3.1.8.1
Zn2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Homo sapiens
3.1.8.1
Zn2+
Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+
Oryctolagus cuniculus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.1.1.2
39800
-
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE
Oryctolagus cuniculus
3.1.1.2
42300
-
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE
Oryctolagus cuniculus
3.1.8.1
additional information
-
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE
Oryctolagus cuniculus
3.1.8.1
40600
-
human serum contains one major species of PON monomer (44300 Da) and a minor species of PON monomer (40600 kDa)
Homo sapiens
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
3.1.1.2
glycoprotein
at least 2 N-linked sugar chains, contains sialic acid residues
Homo sapiens
3.1.1.2
glycoprotein
at least 2 N-linked sugar chains, contains sialic acid residues
Oryctolagus cuniculus
3.1.8.1
glycoprotein
at least 2 N-linked sugar chains, contains sialic acid residues
Homo sapiens
3.1.8.1
glycoprotein
at least 2 N-linked sugar chains, contains sialic acid residues
Oryctolagus cuniculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.2
blood serum
contains A-type paraoxonase and B-type paraoxonase
Homo sapiens
-
3.1.1.2
blood serum
-
Oryctolagus cuniculus
-
3.1.8.1
blood serum
contains A-type paraoxonase and B-type paraoxonase
Homo sapiens
-
3.1.8.1
blood serum
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.2
1-naphthyl acetate + H2O
0.1% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
1-naphthol + acetate
-
-
-
?
3.1.1.2
1-naphthyl acetate + H2O
0.1% of the activity with phenyl acetate, A-type enzyme. 0.25% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
1-naphthol + acetate
-
-
-
?
3.1.1.2
2-naphthyl acetate + H2O
13.5% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
2-naphthol + acetate
-
-
-
?
3.1.1.2
2-naphthyl acetate + H2O
5.5% of the activity with phenyl acetate, A-type enzyme. 7% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
2-naphthol + acetate
-
-
-
?
3.1.1.2
2-nitrophenyl acetate + H2O
2.1% of the activity with phenyl acetate, A-type enzyme. 2% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
2-nitrophenol + acetate
-
-
-
?
3.1.1.2
2-nitrophenyl acetate + H2O
29% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
2-nitrophenol + acetate
-
-
-
?
3.1.1.2
4-nitrophenyl acetate + H2O
2.5% of the activity with phenyl acetate, A-type enzyme. 3.5% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
4-nitrophenol + acetate
-
-
-
?
3.1.1.2
4-nitrophenyl acetate + H2O
31% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
4-nitrophenol + acetate
-
-
-
?
3.1.1.2
phenyl acetate + H2O
-
646527
Homo sapiens
phenol + acetate
-
-
-
?
3.1.1.2
phenyl acetate + H2O
-
646527
Oryctolagus cuniculus
phenol + acetate
-
-
-
?
3.1.1.2
thiophenyl acetate + H2O
27% of the activity with phenyl acetate, A-type enzyme. 34% of the activity with phenyl acetate, B-type enzyme
646527
Homo sapiens
?
-
-
-
?
3.1.1.2
thiophenyl acetate + H2O
30.5% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
?
-
-
-
?
3.1.8.1
paraoxon + H2O
0.2% of the activity with phenyl acetate
646527
Oryctolagus cuniculus
diethylphosphate + 4-nitrophenol
-
-
-
?
3.1.8.1
paraoxon + H2O
A-type paraoxonase shows 0.06% of the activity with phenyl acetate, B-type paraoxonase shows 2.5% of the activity with phenyl acetate
646527
Homo sapiens
diethylphosphate + 4-nitrophenol
-
-
-
?