BRENDA - Enzyme Database

Studies on human serum paraoxonase/arylesterase

La Du, B.N.; Adkins, S.; Kuo, C.L.; Lipsig, D.; Chem. Biol. Interact. 87, 25-34 (1993)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.1.2
1,2-dilauroyl-phosphatidylcholine
stimulation
Homo sapiens
3.1.1.2
dioleoyl phosphatidylcholine
stimulation
Homo sapiens
3.1.1.2
lecithin
stimulation
Homo sapiens
3.1.1.2
lysolecithin
stimulation
Homo sapiens
3.1.1.2
phosphatidylcholine
purified A or B-type esterases are stimulated
Homo sapiens
3.1.1.2
phosphatidylethanolamine
stimulation
Homo sapiens
3.1.1.2
phosphatidylglycerol
stimulation
Homo sapiens
3.1.8.1
dilauroyl phosphatidylcholine
stimulation
Homo sapiens
3.1.8.1
dioleoyl phosphatidylcholine
stimulation
Homo sapiens
3.1.8.1
lecithin
stimulation
Homo sapiens
3.1.8.1
lysolecithin
stimulation
Homo sapiens
3.1.8.1
phosphatidylcholine
purified A or B-type esterases are stimulated
Homo sapiens
3.1.8.1
phosphatidylethanolamine
stimulation
Homo sapiens
3.1.8.1
phosphatidylglycerol
stimulation
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.2
6-palmityl-ascorbic acid
-
Homo sapiens
3.1.1.2
phosphatidylserine
-
Homo sapiens
3.1.8.1
6-palmityl-ascorbic acid
-
Homo sapiens
3.1.8.1
phosphatidylserine
-
Homo sapiens
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.1.2
NaCl
B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
Homo sapiens
3.1.8.1
NaCl
B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.1.2
Homo sapiens
-
-
-
3.1.8.1
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.2
blood serum
in serum, the esterase is tightly bound to the high density lipoproteins, particularly apo A-l
Homo sapiens
-
3.1.8.1
blood serum
in serum, the esterase is tightly bound to the high density lipoproteins, particularly apo A-l
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.2
phenyl acetate + H2O
the enzyme exists in two genetically determined allozymic forms, and these A and B allozymes possess both paraoxonase and arylesterase activities. B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
646509
Homo sapiens
phenol + acetate
-
-
-
?
3.1.8.1
paraoxon + H2O
the enzyme exists in two genetically determined allozymic forms, and these A and B allozymes possess both paraoxonase and arylesterase activities. B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
646509
Homo sapiens
diethylphosphate + 4-nitrophenol
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.1.2
1,2-dilauroyl-phosphatidylcholine
stimulation
Homo sapiens
3.1.1.2
dioleoyl phosphatidylcholine
stimulation
Homo sapiens
3.1.1.2
lecithin
stimulation
Homo sapiens
3.1.1.2
lysolecithin
stimulation
Homo sapiens
3.1.1.2
phosphatidylcholine
purified A or B-type esterases are stimulated
Homo sapiens
3.1.1.2
phosphatidylethanolamine
stimulation
Homo sapiens
3.1.1.2
phosphatidylglycerol
stimulation
Homo sapiens
3.1.8.1
dilauroyl phosphatidylcholine
stimulation
Homo sapiens
3.1.8.1
dioleoyl phosphatidylcholine
stimulation
Homo sapiens
3.1.8.1
lecithin
stimulation
Homo sapiens
3.1.8.1
lysolecithin
stimulation
Homo sapiens
3.1.8.1
phosphatidylcholine
purified A or B-type esterases are stimulated
Homo sapiens
3.1.8.1
phosphatidylethanolamine
stimulation
Homo sapiens
3.1.8.1
phosphatidylglycerol
stimulation
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.1.2
6-palmityl-ascorbic acid
-
Homo sapiens
3.1.1.2
phosphatidylserine
-
Homo sapiens
3.1.8.1
6-palmityl-ascorbic acid
-
Homo sapiens
3.1.8.1
phosphatidylserine
-
Homo sapiens
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.1.2
NaCl
B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
Homo sapiens
3.1.8.1
NaCl
B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.1.2
blood serum
in serum, the esterase is tightly bound to the high density lipoproteins, particularly apo A-l
Homo sapiens
-
3.1.8.1
blood serum
in serum, the esterase is tightly bound to the high density lipoproteins, particularly apo A-l
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.1.2
phenyl acetate + H2O
the enzyme exists in two genetically determined allozymic forms, and these A and B allozymes possess both paraoxonase and arylesterase activities. B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
646509
Homo sapiens
phenol + acetate
-
-
-
?
3.1.8.1
paraoxon + H2O
the enzyme exists in two genetically determined allozymic forms, and these A and B allozymes possess both paraoxonase and arylesterase activities. B-type esterase has relatively higher paraoxonase activity and is stimulated to a greater degree by 1 M NaCl than the A allozyme
646509
Homo sapiens
diethylphosphate + 4-nitrophenol
-
-
-
?