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Literature summary extracted from

  • Gil, F.; Gonzalvo, M.C.; Hernandez, A.F.; Villanueva, E.; Antonio, P.
    Differences in the kinetic properties, effect of calcium and sensitivity to inhibitors of paraoxon hydrolase activity in rat plasma and microsomal fraction from rat liver (1994), Biochem. Pharmacol., 48, 1559-1568.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.1.8.1 loss of activity after dialysis Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.8.1 Ba2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 Co2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 EDTA activity restored by addition of Ca2+; plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 Hg2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 La3+ plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 Mg2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 Mn2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 p-hydroxymercuribenzoate plasma enzyme more resistant than liver enzyme Rattus norvegicus
3.1.8.1 Zn2+ plasma enzyme more resistant than liver enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.8.1 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.8.1 Ca2+ essential activator of rat plasma enzyme, nonessential activator of liver microsomal enzyme Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.8.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.8.1 blood plasma
-
 Rattus norvegicus
-
3.1.8.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.8.1 paraoxon + H2O
-
 Rattus norvegicus diethylphosphate + 4-nitrophenol
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.8.1 additional information
-
 rat plasma enzyme is more stable to heat inactivation than rat liver microsomal enzyme, no loss of activity in human serum after 3 days and 33% after 5 days Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.8.1 6 9
-
 Rattus norvegicus