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Literature summary extracted from

  • Malik, A.S.; Low, M.G.
    Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases (1986), Biochem. J., 240, 519-527.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.50 n-butanol activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.50 Chloropromazine partial Homo sapiens
3.1.4.50 EGTA Ca2+ partially reverses Homo sapiens
3.1.4.50 additional information no inhibition by leupeptin; no inhibition by trifluoperazine Homo sapiens
3.1.4.50 p-Hydroxymercuriphenylsulfonic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.50 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.50 Ca2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O Homo sapiens
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.50 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.50 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O
-
 Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O cleaves phosphodiester linkage to diacylglycerol Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?