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Literature summary extracted from

  • Lips, D.L.; Majerus, P.W.
    The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells (1989), J. Biol. Chem., 264, 19911-19915.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.64 EDTA optimum at 1.5-3 mM Rattus norvegicus
3.1.3.64 EDTA maximally active in the presence of EDTA Rattus norvegicus
3.1.3.64 EGTA activation, optimum at 1.5-3 mM Rattus norvegicus
3.1.3.64 octyl glucoside biphasic dependence of activity on octyl glucoside Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.64 Ca2+ in the millimolar range, 1 mM: 50-75% inhibition Rattus norvegicus
3.1.3.64 Mg2+ in the millimolar range, slightly less potent than Ca2+ Rattus norvegicus
3.1.3.64 additional information not inhibited by EDTA or EGTA Rattus norvegicus
3.1.3.64 VO43- 0.1 mM: 15% inhibition, 0.5 mM: 95% inhibition Rattus norvegicus
3.1.3.64 Zn2+ 0.5 mM: 90% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.64 membrane
-
Rattus norvegicus 16020
-
3.1.3.64 soluble soluble fraction Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.64 additional information no metal ion requirement Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.64 phosphatidylinositol 3-phosphate + H2O Rattus norvegicus enzyme may terminate a metabolic signal or regulate precursor levels for other phosphatidylinositols that are phosphorylated in the D-3 position phosphatidylinositol + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.64 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.64 NIH3T3 cell fibroblast cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.64 additional information not: phosphatidylinositol 4-phosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 1,3-bisphosphate Rattus norvegicus ?
-
?
3.1.3.64 phosphatidylinositol 3-phosphate + H2O specifically removes phosphate from the D-3-ring position of the substrate Rattus norvegicus phosphatidylinositol + phosphate
-
?
3.1.3.64 phosphatidylinositol 3-phosphate + H2O enzyme may terminate a metabolic signal or regulate precursor levels for other phosphatidylinositols that are phosphorylated in the D-3 position Rattus norvegicus phosphatidylinositol + phosphate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.64 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.64 6.5
-
about Rattus norvegicus
3.1.3.64 6.8
-
assay at Rattus norvegicus