EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.3.53 | a 72.5 kDa N-terminal fragment of the 110 kDa subunit is cloned | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.53 | arachidonic acid | inhibits SMPP-1M, dissociates the catalytic subunit from the native holoenzyme, inhibits the regulatory action of the 110 kDa/21 kDa subunit complex on the catalytic subunit PP1C activity, the C-terminal half of the 110 kDa subunit is required for inhibition | Sus scrofa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.3.53 | 21000 | - |
1 * 110000 + 1 * 37000 + 1 * 21000, enzyme SMPP-1M, 37 kDa catalytic subunit PP1C, 110 kDa regulatory subunit M110 | Sus scrofa |
3.1.3.53 | 37000 | - |
1 * 110000 + 1 * 37000 + 1 * 21000, enzyme SMPP-1M, 37 kDa catalytic subunit PP1C, 110 kDa regulatory subunit M110 | Sus scrofa |
3.1.3.53 | 110000 | - |
1 * 110000 + 1 * 37000 + 1 * 21000, enzyme SMPP-1M, 37 kDa catalytic subunit PP1C, 110 kDa regulatory subunit M110 | Sus scrofa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.53 | Rattus norvegicus | - |
72.5 kDa N-terminal fragment of the 110 kDa subunit | - |
3.1.3.53 | Sus scrofa | - |
SMPP-1M | - |
3.1.3.53 | Sus scrofa SMPP-1M | - |
SMPP-1M | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.1.3.53 | SMPP-1M, subunits M110, M21 and PP1C catalytic subunit | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.53 | aorta | fragments of the 110 kDa subunit | Rattus norvegicus | - |
3.1.3.53 | bladder | SMPP-1M | Sus scrofa | - |
3.1.3.53 | kidney | 72.5 kDa N-terminal fragment of the 110 kDa subunit | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.53 | additional information | studies with fragments of the 110 kDa subunit on their ability to regulate relaxation and 20 kDa myosin light-chain dephosphorylation of rabbit permeabilized portal vein induced by the catalytic subunit PP1C | Rattus norvegicus | ? | - |
? | |
3.1.3.53 | additional information | studies with fragments of the 110 kDa subunit on their ability to regulate relaxation and 20 kDa myosin light-chain dephosphorylation of rabbit permeabilized portal vein induced by the catalytic subunit PP1C | Sus scrofa | ? | - |
? | |
3.1.3.53 | additional information | studies with fragments of the 110 kDa subunit on their ability to regulate relaxation and 20 kDa myosin light-chain dephosphorylation of rabbit permeabilized portal vein induced by the catalytic subunit PP1C | Sus scrofa SMPP-1M | ? | - |
? | |
3.1.3.53 | myosin light-chain phosphate + H2O | 20 kDa myosin light chain | Sus scrofa | myosin light-chain + phosphate | - |
? | |
3.1.3.53 | myosin light-chain phosphate + H2O | 110 kDa/21 kDa complex accelerates dephosphorylation induced by the catalytic subunit PP1C by 1.6fold, the N-terminal sequence 1-309 of the 110 kDa subunit is sufficient to enhance the PP1C activity in muscle | Sus scrofa | myosin light-chain + phosphate | - |
? | |
3.1.3.53 | myosin light-chain phosphate + H2O | 20 kDa myosin light chain | Sus scrofa SMPP-1M | myosin light-chain + phosphate | - |
? | |
3.1.3.53 | myosin light-chain phosphate + H2O | 110 kDa/21 kDa complex accelerates dephosphorylation induced by the catalytic subunit PP1C by 1.6fold, the N-terminal sequence 1-309 of the 110 kDa subunit is sufficient to enhance the PP1C activity in muscle | Sus scrofa SMPP-1M | myosin light-chain + phosphate | - |
? | |
3.1.3.53 | phosphorylated myosin + H2O | - |
Sus scrofa | myosin + phosphate | - |
? | |
3.1.3.53 | phosphorylated myosin + H2O | - |
Sus scrofa SMPP-1M | myosin + phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.3.53 | heterotrimer | 1 * 110000 + 1 * 37000 + 1 * 21000, enzyme SMPP-1M, 37 kDa catalytic subunit PP1C, 110 kDa regulatory subunit M110 | Sus scrofa |